Properties
Description
Lentinan-raltitrexed, denoted raltitrexed-lentinan, constructs a thymidylate synthase inhibitor conjugate through covalent bonding to lentinan's polysaccharide chains. The chemotherapeutic hybrid preserves triple-helix conformation while optimizing antimetabolite delivery via thymus-mediated immunological routes.
Glycan Structure
Its glycan structure is a β-(1→3)-linked d-glucose backbone with β-(1→6)-glucosyl side branches.
Source
Chemical synthesis
Functional Group
Raltitrexed
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Lentinan-raltitrexed can be used for its potential to study platinum drug conjugation effects on DNA crosslinking efficiency in cancer cell lines.
