Overview of DNA-encoded Glycoprotein Degrader Library

In the current field of biomedical research, there is a growing need to target specific glycoproteins and degrade them. The DNA-encoded glycoprotein degrader library is a cutting-edge technology that enables the development of novel therapeutics by combining the high-throughput screening advantages of DNA-encoded chemical glycan libraries (DEGLs) with the ability to target and degrade glycoproteins. CD BioGlyco has a professional DEGL research team with state-of-the-art high-throughput screening technology to provide custom DNA-encoded glycoprotein degrader library solutions to clients in different fields to help them accelerate the screening and optimization of glycoprotein degraders.

Revolutionize Drug Discovery with DNA-encoded Glycoprotein Degraders

Based on the needs of our clients, we provide them with comprehensive solutions for DEGDL. Our services cover several key steps from the design of initial DNA-encoded chemical libraries to the validation of efficient glycoprotein degraders, ensuring that our clients have access to glycoprotein degradation candidate molecules with high specificity and activity.

Construction of DNA-encoded Glycoprotein Degrader Library

We use high-precision DNA synthesis technology to encode the designed sequences into single- or double-stranded DNA molecules. These encoded DNAs serve not only as markers but also as linkers to efficiently bind the glycoprotein degradant structural units to the target glycoproteins. We employ appropriate DNA-compatible reactions to bind degraders to encoded DNA molecules to obtain stable and potent DNA-encoded glycoprotein degrader compounds. Each glycoprotein degrader compound is labeled by a unique DNA coding sequence to ensure accurate identification in subsequent screening. The DNA-compatible reactions we employ in the above process include the construction of amide bonds, the conversion of carbonyl functional groups, the formation of specific chemical bonds (e.g., C-C bonds, C-O bonds, C-P bonds, etc.), and others. We also develop novel DNA-compatible Reactions to meet the specific needs of our clients.

In addition, our DEGL experts also construct DNA-encoded glycoprotein degrader libraries at different scales, ranging from millions to tens of millions, according to the research needs of different clients, to accelerate the progress of their research.

Workflow

By combining advanced DNA encoding technology and chemical synthesis methods, we offer a complete and efficient workflow for DNA-encoded glycoprotein degrader library construction and screening. Please refer to the flowchart below to learn more about the steps and benefits of our services.

Applications

• The DNA-encoded glycoprotein degrader library can be used to screen and identify molecules capable of selectively degrading specific proteins, especially those involved in diseases, such as cancer-associated proteins and neurodegenerative disease proteins.
• DNA-encoded glycoprotein degrader library screening compounds with selective degradation of target proteins can be used to help researchers gain insights into the specific roles of proteins in cellular processes and pathologies.
• The compounds screened by the DNA-encoded glycoprotein degrader library to degrade specific glycoproteins can be used to discover disease-related biomarkers, thus contributing to early disease research.

Advantages

• We use cutting-edge DNA-encoding technology to ensure that each glycoprotein degrader compound is accurately labeled and identified.
• We provide different scales of DNA-encoded glycoprotein degrader libraries according to the specific needs of our clients to accelerate the progress of their projects.
• We provide a one-stop solution for designing, constructing, screening, and analyzing the DNA-encoded glycoprotein degrader library. Clients only need to provide the requirements and we will take care of all the technical details.

Publication Data

Frequently Asked Questions

• What is glycoprotein degrader?
  • Glycoprotein degrader is a compound or molecular tool that specifically recognizes, binds, and degrades glycoproteins. At the molecular level, glycoprotein degrader can trigger the degradation of glycoproteins by two main mechanisms: protein hydrolysis-targeted chimeras and lysine-dependent glycoprotein hydrolases.
• Can compounds in the DNA-encoded glycoprotein degrader library be further optimized?
  • We carried out the Chemistry-driven DEGL Design in advance and selected the sugar compounds with better activity as building blocks to construct the compound library.

With advanced DNA coding technology and expertise in molecular biology, CD BioGlyco provides clients with customized comprehensive solutions for DNA-encoded glycoprotein degrader libraries. We help clients in different fields to make breakthroughs in glycoprotein degradation in their research projects with our state-of-the-art DEGL technology platform and professional services. Please feel free to contact us if you are interested in our DNA-encoded glycoprotein degrader library.

• DNA-encoded Single-Pharmacophore Glycan Library
• DNA-encoded Dual-Pharmacophore Glycan Library
• DNA-encoded Trio-Pharmacophore Glycan Library
• Solid Phase-based DNA-encoded Glycan Library (DEGL)
• Liquid Phase-based DNA-encoded Glycan Library (DEGL)
• DNA-encoded Natural Glycan Library
• DNA-encoded Modified Glycan Library
• DNA-encoded Glycan Antigen Library
• DNA-encoded Glycopeptide Library
• Monovalent DNA-encoded Glycan Library (DEGL)
• Multivalent DNA-encoded Glycan Library (DEGL)
• Scaffold-based DNA-encoded Glycan Library (DEGL)
• Target-based DNA-encoded Glycan Library (DEGL)
• DNA-encoded Glycan Macrocycle Library
• DNA-encoded Glycan Covalent Inhibitor Library
• DNA-encoded Glycan Allosteric Inhibitor Library
• Light Crosslinking DNA-encoded Glycan Library (DEGL)
• DNA-encoded Dynamic library (DEDL)
• Coupling Reaction-based DNA-encoded Glycan Library (DEGL)
• Multi-component Reaction-based DNA-encoded Glycan Library (DEGL)
• Photocatalytic Cycloaddition-based DNA-encoded Glycan Library (DEGL)
• Aromatic Heterocyclization-based DNA-encoded Glycan Library (DEGL)
• Non-aromatic Heterocyclization-based DNA-encoded Glycan Library (DEGL)
• Carbocyclization-based DNA-encoded Glycan Library (DEGL)
• Macrocyclization-based DNA-encoded Glycan Library (DEGL)
• Click Chemistry-based DNA-encoded Glycan Library (DEGL)