Unlock the Sweet Science: Precision Modeling with Glycoinformatics

Carbohydrates are a class of biomolecules with diverse structures and functions. In cells, they are involved in energy storage, signaling, and intercellular recognition. Therefore, the research of carbohydrate structure and function is another major frontier to explore the mystery of life after protein and nucleic acid. As a professional company engaged in research on glycoscience, CD BioGlyco integrates informatics technology to provide comprehensive Carbohydrate Analysis and Structure Prediction Services.

Here, we provide our clients with high-quality carbohydrate structure modeling services to help them correctly determine the type of carbohydrate structure and facilitate the application development of carbohydrates.

Our carbohydrate structure modeling usually involves these stages:

• Firstly, molecular dynamics (MD) is used by our experts to calculate the various types of atoms in the carbohydrate structure and to simulate the carbohydrate structure at the atomic level.
• Secondly, the main focus is on MD simulations or virtual molecular docking experiments of carbohydrates using computer technology. The main task in this phase is to generate enough information to accurately predict the structural features of carbohydrates and to deeply analyze the conformational relationships of carbohydrates.
  • Examples include information on the bond lengths, bond angles, conformations, intramolecular hydrogen bonding, van der Waals, and electrostatic forces of carbohydrates. This information provides information about changes in the positions of atoms in carbohydrates, allowing researchers to accurately capture key structural transformations.
• In the third stage, we analyze the results using informatics techniques. In this stage, reliable experimental data are utilized to validate the carbohydrate structure modeling procedure. Specific information from the modeling research is converted into concrete data. The conformational, energetic, and kinetic properties of carbohydrates are calculated using informatics techniques to provide key insights for their structural and kinetic research.

In addition, we apply nuclear magnetic resonance (NMR) techniques to the modeling process and thus analyze the 3D structure of carbohydrates. For example, the results of computer simulations provide evidence for structural information derived from NMR spectra, such as coupling constants or effective proton-proton distances.

Publication Data

Applications

• Glycoinformatics-assisted carbohydrate structure modeling can be used to analyze the changes in cell surface glycans, which can help researchers study the surface glycan structure of pathogens in depth and design and develop novel drugs and vaccines.
• Glycoinformatics-assisted carbohydrate structure modeling can be used to simulate the behavior of carbohydrates under different conditions, which can help researchers to accurately analyze complex carbohydrate structures.
• Glycoinformatics-assisted carbohydrate structure modeling can be used to fully simulate the changes in carbohydrates during food processing, which can help researchers to understand the structure and function of carbohydrates in food and to design and develop functional foods.

Advantages

• We have a team of professionals in many fields, such as chemistry, biology, informatics, etc., who provide high-level glycan structure modeling services.
• We have advanced computer simulation, machine learning, artificial intelligence, and other technologies that enable us to model glycan structures quickly and accurately.
• We provide diversified glycan structure simulation services, including the Modeling of the Structure of different types of glycoconjugates with different functions, and provide custom solutions according to customer needs.

Frequently Asked Questions

• What are the applications of glycoinformatics in food science?
  • The use of glycoinformation technology allows a comprehensive and scientific understanding of the structure of complex carbohydrates (especially polysaccharides) in food. Analyzing the structure and function of sugars in food, helps experts to optimize food processing and improve the quality and safety of food. It can also promote in-depth research on the process of carbohydrate digestion and metabolism in the body, the role of health functions, as well as the ways and mechanisms involved in life activities.
• What basic knowledge is required for carbohydrate structure modeling using glycoinformatics?
  • We typically require a basic knowledge of biology, chemistry, and computer science, but specific requirements will vary depending on the practical application and tools used.
  • Biology: Knowledge of carbohydrate structure and function as well as carbohydrate biosynthesis and metabolic pathways.
  • Chemistry: knowledge of the effects of chemical bonding and molecular structure on the molecular form of carbohydrates.
  • Computational biology and bioinformatics: Knowledge of molecular modeling and simulation techniques, basic operation of commonly used molecular modeling and data analysis software, and knowledge of how to use and query relevant bioinformatics databases.

CD BioGlyco has the expertise and rich experience in the field of glycoinformatics and provides high-quality, accurate, and reliable glycan structure modeling services to researchers from all walks of life. We help our clients to correctly determine the structure types of various complex carbohydrates through our powerful computational capabilities and advanced algorithmic techniques. Please feel free to contact us if you are interested in our glycan structure modeling service.

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