Precision Meets Your Automated Glycan Synthesis with Glycoinformatics

With the knowledge accumulation in the field of glycobiology and bioinformatics, CD BioGlyco has constructed an unparalleled Glycobioinformatics Platform, using computational tools to integrate advanced informatics into the structural and functional research of glycans. We provide many services guided by glycobioinformatics, such as Glycan Synthesis Services, Glycan-related Drug Development Services, Interaction Analysis, Glycomics Analysis, etc.

Glycan synthesis is an important part of glycobiology research, affecting drug development, drug delivery, crop improvement, and other fields. Common methods for glycan synthesis include:

• Chemical synthesis: Total synthesis and chemoenzymatic synthesis. Total synthesis is the stepwise synthesis of complex glycan structures starting from simple non-glycans, requiring multiple protection and deprotection steps. Chemoenzymatic synthesis combines chemical synthesis with enzymatic processes, using the specificity of enzymes to build complex glycans.
• Enzymatic synthesis: Using glycosyltransferases to transfer sugar moieties from donors to acceptor molecules or using glycosidases to trim and reshape glycans.
• Solid-phase synthesis: Using automated machines to add monosaccharides in a highly controlled stepwise manner, reducing human intervention.
• Modular synthesis: Synthesizing smaller glycan units or modules that can be assembled into more complex structures.

We apply bioinformatics tools to glycan synthesis to achieve automatic design and synthesis of complex glycans, thereby accelerating the research and application process. We provide the following two services:

• Glycoinformatics-guided Enzymatic Modular Assembly Service for Glycan Synthesis
• Glycoinformatics-guided Automated Glycan Synthesis Service

Automated glycan synthesis service is a high-precision, high-speed, and high-reproducibility synthesis technology that combines advanced computer systems and glycoinformatics to automatically synthesize complex glycans. We provide glycobioinformatics-guided automated glycan synthesis services to clients around the world, aiming to help scientists and researchers accelerate the synthesis of complex carbohydrates. Our service process is as follows:

• Synthesis scheme design: Use computational models to design the optimal synthesis pathway and enzyme combination of glycans, and use database information to screen reaction conditions.
• Automated glycan assembly: Use automated synthesizers to perform enzymatic and chemical steps step by step according to the synthesis scheme.
• Quality control: Apply techniques such as mass spectrometry, nuclear magnetic resonance, and high-performance liquid chromatography to analyze the purity and structure of synthesized glycans.

Publication

Applications

• Biological research: Glycans play a key role in cell signaling, molecular recognition, and immune response. Synthesizing specific glycans helps you understand these biological processes.
• Drug development: Glycan-related drugs are produced through automated glycan synthesis technology guided by glycobioinformatics for the treatment of cancer and other related diseases.
• Vaccine production: Glycan antigens are an integral part of vaccine design. Rapid and precise synthesis of glycans helps in vaccine development.
• Cancer marker development: Synthesize common cancer markers for disease detection.

Advantages of Us

• With our knowledge in bioinformatics and glycan synthesis, our scientists will customize the best project plan for you and continuously optimize it to better meet your project needs.
• Our synthesis method has the advantages of high synthesis efficiency, good accuracy, and good reproducibility.
• We use this technology to help you produce glycans of various scales from small batches to large batches.
• We use this technology in the synthesis of glycans in many fields, such as agriculture, medicine, pharmacy, etc.

Frequently Asked Questions

• How does glycoinformatics guide glycan synthesis?
  Glycoinformatics uses computational tools to mine a large amount of information about the structure, function, and synthesis route of glycans in the database, and integrates these resources to design the best synthesis route and reaction conditions. During the reaction process, glycoinformatics continuously optimizes the reaction conditions to maximize the reaction conditions and increase the yield.
• What are the advantages of the automated glycan synthesis service guided by glycobioinformatics?
  The best synthetic pathways are designed by analyzing extensive glycan databases and modeling programs; Advanced automation technology is used to assemble glycans, reducing labor costs; Multiple synthetic projects are processed simultaneously with high efficiency; Synthetic data are highly reproducible with the help of advanced computer systems.

At CD BioGlyco, our automated glycan synthesis service will assist your research in many fields such as drug development, vaccine development, crop improvement, etc. If you are interested in our services, please feel free to contact us for more information.

• Glycoinformatics-guided Enzymatic Modular Assembly Service for Glycan Synthesis