Computational Model-assisted Hyper-glycosylated Analog Design Service
Rational Design of Hyper-glycosylated Analog
Hyper-glycosylation is a special point of glycosyl engineering for the introduction of new N-glycosylation sites. It may enhance protein secretion by promoting proper folding of the protein in addition to its effect on the pharmacokinetics of the protein. Relying on advanced algorithms, CD BioGlyco provides one-stop hyper-glycosylated analog design services including site selection, prediction of structural and functional changes due to amino acid sequence changes, analog structure design, model evaluation, and more. If you are interested in other
Specific Models, our researchers offer you custom modeling services.
Selection of potential N-glycosylation sites
The selection of suitable sites on the protein surface for the introduction of N-glycosylation sites is the basis and key to the whole service. We utilize computational strategies to select suitable sites for the introduction of new N-glycosylation sites. Our researchers evaluate residues involved in protein structure or function to screen possible sites for probability analysis of the occurrence of N-glycosylation.
Design and selection of analogs
For the screened potential positions, we provide analog design services and N-glycosylation efficiency prediction services for each position.
Our researchers generate three-dimensional (3D) structures of selected analogs by homology modeling. Molecular dynamics simulations are used to predict the stability of the analogs and to predict structural changes due to changes in amino acid sequence.
Applications of Hyper-glycosylated Analog Design
- Hyper-glycosylated analog design can be used to extend the serum half-life of valuable protein therapeutics.
- Hyper-glycosylated analog design can be used to improve protein properties such as solubility, stability, folding, and secretion.
- Hyper-glycosylated analog design can be used to improve the physicochemical and pharmaceutical properties of therapeutics.
Advantages of Us
- CD BioGlyco provides customized hyper-glycosylated analog design services based on client needs including but not limited to hyper-glycosylated human luteinizing hormone analogs, hyper-glycosylated interferon beta analogs, and hyper-glycosylated human chorionic gonadotropin analogs.
- Our operations team has extensive hyper-glycosylated modeling experience to deal with issues that may arise.
- Based on the different glycosyl analogs, our experienced experts provide the most appropriate algorithms for modeling and prediction.
Frequently Asked Questions
- What are the advantages of using computational models to introduce new glycosylated microstores?
- The use of computer modeling to discover and introduce glycosylation sites for rapid design of hyper-glycosylated analogs with the property that molecular changes in the amino acid sequence have minimal impact on the 3D structure. It has high stability and receptor binding capacity and also does not delay the glycosylation process.
- How to avoid 3D structural alterations of proteins due to amino acid sequence changes?
- Evaluation of molecular stability and flexibility of structures by molecular dynamics simulations. In modeling, the addition of new N-glycosylation sites in the ring region is a good approach for maintaining the 3D structure of proteins.
CD BioGlyco uses a range of software tools and computing resources to help clients complete hyper-glycosylated analog design quickly. Our staff has extensive experience in the industry and responds quickly to your every need. For any further information, do not hesitate to contact us.
For research use only. Not intended for any diagnostic use.
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