Glycan NMR Spectrometry Data Interpretation, Integration and Visualization
Transform NMR Analysis with Intuitive Design and Intelligent Data Analysis
NMR spectroscopy is an excellent tool for structural characterization of carbohydrates. 15N, 2H, and 13C nuclei are sensitive to the relaxation times T1, T2, and the heteronuclear overhauser effect (NOE) on the motion of glycan molecules. Our Glycan Data Visualization team provides local dynamics analysis and glycan spatial distribution map resolution services. Based on Glycoinformatics-assisted Analysis/Prediction, CD BioGlyco provides a diversified NMR data model for analyzing structures in the data, and also for visualizing and interpreting specific spectral properties.
Data collection and modeling
Combining information on pathways, atomic positions, experimental data, molecular geometry, topology, and interactions, our lab provides data modeling and application development services. Our models support customization according to the different parameter requirements of our clients.
NMR data multivariate statistical analysis
CD BioGlyco provides accurate glycan NMR spectrometry data interpretation, integration, and visualization services with an easy-to-use interface and experienced technicians. Our personnel quickly filter and extract valid data through intelligent data parsing.
Whether you want to process with glycan 1D NMR data or 2D data, our lab provides you with professional data visualization services.
With the help of professional services such as zooming, integral calculation displays, and customizable contour plots, we offer you special data point interpretation services.
Publication
Technology: Stochastic modeling, NMR spin relaxation, Semi-flexible Brownian (SFB) model
Journal: Molecules
Published: 2021
IF: 4.2
Results: In this study, a new strategy for data resolution and evaluation of magnetic resonance relaxation experiments was developed using the SFB model. Combining SFB with the 13C NMR relaxation parameters T1 and T2, the researchers calculated estimates of the 13C-NMR parameters T1, T2, and NOE for selected CH and methylene probes. To determine feasibility, the researchers validated the new strategy using a set of oligosaccharides. Overall, this generalized strategy can be applied to different kinds of molecular systems.
Fig.1 Selection of reference atoms and reference coordinate systems in the calculation of NMR relaxation observables. (Rampino, et al., 2021)
Applications
- Glycan NMR spectrometry data visualization is suitable for rapid characterization of high-volume glycan NMR datasets.
- Glycan NMR spectrometry data visualization provides a pathway for visualizing other biomolecular datasets.
- Glycan NMR spectrometry data visualization greatly facilitates the identification of potential glyco-biomarkers.
Advantages of Us
- The visualization services we provide are fast and powerful, saving time for our clients in organizing their NMR data upfront.
- We offer visualization tools that improve spectral resolution by "fingerprinting" the chemical structure and composition of the sample in greater detail.
- Our researchers use baseline multipliers and increments for accurate contour calculations.
Frequently Asked Questions
- What are the powerful tools for quantifying differences between spectra and extracting potential spectral information associated with a particular response?
- Commonly used chemometric tools such as principal component analysis (PCA), partial least squares projection of latent structures (PLS), or orthogonal projection of latent structures (OPLS).
- What types of NMR data can be processed by these data models and applications?
- We support 1D and 2D NMR data processing including but not limited to COSY, TCOSY, HSQC, and NOESY. These tools automatically scale the data dimensions and process them.
- Is it possible to customize the NMR visualization display?
- Sure. We offer customizable ribbons including but not limited to switching resolutions, adjusting baselines, switching contour plots, and switching heat maps.
CD BioGlyco makes data integration and visualization easy by simplifying NMR analysis. Our goal is powerful visualization tools to effectively interpret your data. No matter what problems you encounter in your glycan NMR spectrometry data visualization, please feel free to contact us.
Reference
- Rampino, S.; et al. Stochastic modelling of 13C NMR spin relaxation experiments in oligosaccharides. Molecules. 2021, 26(9): 2418.
For research use only. Not intended for any diagnostic use.
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