Glycoinformatics-assisted Glycolipid Structure Modeling Service
Accurate Modeling of Glycolipids Through Cutting-edge Technology
Glycolipid molecules are ubiquitous and mediate a wide range of physiological and pathological processes such as growth, immunity, development, and microbial invasion. Characterizing their structure and dynamics is essential for understanding their biological roles. Based on our hands-on experience and extensive knowledge in Structural Modeling, CD BioGlyco provides a glycoinformatics-assisted glycolipid structure modeling service with high accuracy. We tailor our solutions to the goals and specific requirements of each client, ensuring personalized Analytical and Predictive support.
As with other glycoconjugates, the elucidation of the 3D structure of glycolipids relies on computational modeling, nuclear magnetic resonance (NMR), and more. We have experts with extensive experience in areas such as glycoinformatics, allowing us to offer customized glycolipid structure modeling services. The accurate models constructed help to further investigate the structure-activity relationships, kinetics, etc., of glycolipids.
Structural characterization of glycolipids
Structural characterization of glycolipids involves determining the composition of lipids and glycans, types of linkages, isomeric configurations, branching information, and more. We have a variety of advanced experimental techniques to determine these characteristics, including thin layer chromatography (TLC), NMR, gas chromatography-mass spectrometry (GC–MS), etc.
Structural modeling
Based on our expertise in computational biology and other areas, we provide a highly accurate and reliable structural modeling service of glycolipids, including data mining, modeling, and model optimization to accelerate our clients' research progress. Our team uses efficient modelers to simplify the construction of glycolipid structure models and consider characteristics such as carbohydrate type, glycosidic bonding, chemical modifications, etc., to ensure the accuracy of the models. Ultimately, computer design provides clues to the structural and kinetic properties of glycolipids, providing insights at the atomic level.
We maintain communication with our clients at all times throughout the process to ensure project transparency. In addition to glycolipid modeling results, we also provide raw data and analysis of calculated results.
Publication Data
Technology: Molecular dynamics (MD) and molecular mechanics (MM) calculations
Journal: International Journal of Molecular Sciences
IF: 5.923
Published: 2020
Results: This paper provides a detailed summary of the molecular modeling, databases developed, structure visualization tools, and experimental data validation services that have been used for structural studies of glycolipids, glycoproteins, etc., in recent years. Some of the web-based tools that have been developed for the structural modeling of glycolipids and other structures, such as the CHARMM-GUI modeler, are mentioned. These versatile online computer-based molecular modeling services allow starting from structure input and automating subsequent procedures, which have important applications in structural modeling such as glycolipids.
Applications
- Glycolipid structure modeling plays an important role in studying the role of glycolipids in cell-cell recognition, nervous system development, etc.
- Glycolipid structure modeling contributes to a deeper understanding of the structure, dynamics, and underlying mechanisms of complex glycolipid-containing biological membrane systems.
- Glycolipids are usually located on the surface of cell membranes. Glycolipid structure modeling helps to characterize the structure-function relationship of glycolipids in lipid membranes.
Highlights
- Our experienced glycoinformatics team, coupled with our robust technical facilities, enables us to effectively meet a wide range of project requirements.
- We tailor our modeling solutions to the specific goals of our clients to ensure tailored research support.
- Our glycolipid structure modeling service is highly accurate and precise with short cycle times.
Frequently Asked Questions
- What are the functions of glycolipids?
- Glycolipids interact with growth factor receptors to regulate cell proliferation.
- Carbohydrates on glycolipids have many binding sites and are involved in cell-cell interactions.
- Selectins bind to carbohydrates on glycolipids and trigger an immune response. In addition to this, glycolipids are involved in viral recognition of host cells.
- What tools are available for glycolipid structure modeling?
- There are several analytical tools available for glycolipid structure generation and modeling, such as the following:
- CHARMM-GUI modeler: It is used for 3D structure generation and modeling of glycolipids, etc.
- doGlycans standalone framework: It is used for the preparation of atomic models of glycolipids, glycoproteins, etc.
- CHARMM-GUI Membrane Builder: It is used to construct complex biofilm systems containing glycolipids, etc.
CD BioGlyco provides a high-quality glycoinformatics-assisted glycolipid structure modeling service and follows strict working standards to ensure the reliability of the models. Welcome to contact us if you need glycolipid structure modeling.
Reference
- Scherbinina, S.I.; Toukach, P.V. Three-dimensional structures of carbohydrates and where to find them. International journal of molecular sciences. 2020, 21(20): 7702.
For research use only. Not intended for any diagnostic use.
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