Glycoinformatics-assisted Proteoglycan Structure Modeling Service
Accurate Proteoglycan (PG) Structure Modeling Through Cutting-edge Algorithms
PGs are important components of the extracellular matrix and cell membranes, facilitate cell-to-cell interactions, and are associated with a variety of diseases. Based on our extensive experience in Structural Modeling, CD BioGlyco offers a state-of-the-art glycoinformatics-assisted PG structure modeling service. With years of Analytical and Predictive experience, we have the confidence and ability to accomplish a wide range of challenging projects.
Our team of experts customizes experimental protocols according to client requirements and uses flexible algorithms to model PG structures. The generated PG structure models are validated and suitable for a wide range of studies. Below are the types of services we offer.
PG structure detection
PG consists of one or more Glycosaminoglycan (GAG) chains and a core protein. We analyze the GAG sequence and conformation by Nuclear magnetic resonance (NMR) and other means. These experimental data help to improve the accuracy of modeling.
PG structural modeling
We utilize cutting-edge algorithms and software to analyze and build structural models of PGs with high precision. This process includes structural data collection, modeling, and model optimization.
- Data collection: We collect relevant PG structures and related data for analysis and modeling.
- Modeling: We use advanced computational tools and algorithms to construct accurate and reliable PG structure models.
- Model optimization: Structures are optimized by simulating molecular dynamics to improve the reliability and accuracy of PG structure models.
We are always client-focused and maintain constant communication to ensure project transparency and maximize client satisfaction. In the end, we provide comprehensive results, including raw data, PG structural models, and detailed analysis reports.
Publication Data
Technology: Fine-grained simulation, coarse-grained (CG) simulation
Journal: Biomacromolecules
IF: 5.583
Published: 2015
Results: In this study, the researchers extend the CG method to accurately characterize heterogeneous GAG and PG on the atomic scale and use these data to further optimize the CG model. They also constructed a realistic atomic model of PG based on X-ray diffraction data, etc., and validated the resulting model by comparing it with hydrodynamic measurements. Finally, the atomic structures of the heterogeneous GAG and PG were precisely visualized, which helped to deeply explore the relationship between structure and dynamics. The described atomic-scale views of heterogeneous GAG and PG provide theoretical support for understanding their functions and applications in the development of biomaterials, as well as guidance for the construction of our structural models of PG.
Fig.1 Average conformer of simulated human bikunin. (Sattelle, et al., 2015)
Applications
- Glycoinformatics-assisted PG structure modeling is used to gain insights into PG assembly, protein interactions, and intercellular interactions.
- Modeling of PG structure helps to elucidate the role of PG in health and neurodegenerative diseases, cancers, etc.
- Structural modeling of PG helps to advance research related to its use as a therapeutic agent.
Highlights
- Our team consists of experts with extensive experience in computational biology and glycoinformatics to ensure reliable results for our clients.
- We utilize advanced methodologies and technologies to ensure that our PG structure modeling services are efficient and accurate. Our team is always on call to provide technical support and solve modeling-related problems.
- Our algorithms are designed to be flexible and the solutions we develop for each PG structural modeling project are unique to meet the client's specific project goals.
Frequently Asked Questions
- What are the functions of PG?
- As an important component of cells, PG has important roles in cell-cell interactions, signaling, etc.
- Cellular functions: Studies on humans, Drosophila, mice, etc., have shown that PG is associated with cell growth and differentiation.
- Interaction: PG exists on the cell surface and is involved in cell-substrate, cell-cell, and cell-ligand interactions.
- Signal transduction: Studies have shown that cell surface PG is involved in multiple signaling pathways associated with cell proliferation and changes in cell shape.
- What is the role of PG in cancer?
- PGs are highly glycosylated proteins that generally consist of a core protein and covalently linked GAG chains. Studies have shown multiple effects of PG on tumor cell growth and metastatic dissemination of cancer cells. For example, ab initio expression of core PGs in breast cancer cell lines inhibits anchorage-independent growth and proliferation. The transmembrane chondroitin sulfate PG 4 positively regulates cancer cell proliferation. Modeling and analysis of the PG structure helps to gain insight into the mechanism of cancer development and thus provides valuable information for the study of cancer therapeutic approaches.
CD BioGlyco is committed to being at the forefront of technological advances and providing a reliable glycoinformatics-assisted PG structure modeling service. Welcome to contact us to learn more about our PG structure modeling and how we support your research efforts with cutting-edge solutions.
Reference
- Sattelle, B.M.; et al. Proteoglycans and their heterogeneous glycosaminoglycans at the atomic scale. Biomacromolecules. 2015, 16(3): 951-961.
For research use only. Not intended for any diagnostic use.
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