Glycoinformatics-assisted Malaria Glycomics Analysis Service
Decoding the Role of Glycans in Malaria
Malaria is a parasitic infectious disease that infects humans and other animals. As technology continues to advance, scientists are finding that glycobiology plays a major role in the in-depth study of malaria, because most of the interactions are mediated by the carbohydrate or glycan portion that decorates the surface of the parasite and the host cell. CD BioGlyco provides the most comprehensive malaria glycomics analysis services with our professional glycobiology experts. Our researchers have proven experience in
Glycoinformatics-assisted Glycomics Analysis, especially
Disease Glycomics Analysis.
Glycan composition analysis
In malaria parasites, CD BioGlyco provides high-quality glycan abundance analysis including N-glycans, O-glycans, C-glycans, and glycosylphosphatidylinositols (GPIs).
Although the presence of N-glycans, O-glycans, and C-glycans in malaria parasites is very limited, our researchers provide accurate analysis and visualization of data evaluation services.
Relying on our reliable staff, CD BioGlyco provides N-glycan and N-glycosylation site identification services to elucidate the functional mechanism of proteins. Moreover, we provide C-mannosylation, α-galactosylation O-glycosylation analyses such as O-fucosylation and O-glcNAcylation analysis.
Molecular modeling
Our researchers construct special molecular models based on molecular biology information provided by our clients. Our computational staff provides binding site prediction and identification services, binding free energy calculation and optimization services, ligand structure design services, key structure fragment prediction and characterization services, and data statistics and presentation services.
Publication
Technology: SPR analysis, Molecular modeling, Molecular docking, Immunofluorescence microscopy, In vitro growth inhibition assay (GIA)
Journal: Cell Reports
Published: 2024
IF: 7.5
Results: In this work, researchers identified a novel targeted glycan lectin, P. falciparum cysteine-rich protective antigen (PfCyRPA), which includes 2-6-linked N-acetylneuraminic acid (Neu5Ac) at its terminus. The researchers predicted the PfCyRPA binding site by molecular modeling and mutagenesis-assisted validation. After a series of analyses, it was shown that modification of PfCyRPA lectin activity through targeting is a potential pathway for the development of malaria therapeutics.
Fig.1 Molecular model of PfCyRPA in complex. (Day, et al., 2024)
Applications
- Glycoinformatics-assisted malaria glycomics analysis helps to develop anti-malarial drugs.
- Glycoinformatics-assisted malaria glycomics analysis helps to discover new therapeutic targets in hosts and parasites.
- Glycoinformatics-assisted malaria glycomics analysis is an effective tool for elucidating the mechanisms of carbohydrate-malaria interactions.
- Glycoinformatics-assisted malaria glycomics analysis lays the foundation for other studies of disease-carbohydrate interactions.
Advantages of Us
- CD BioGlyco remains at the forefront of glycobiology and glycoinformatics, updating and expanding our services to meet the specific needs of our clients.
- Our researchers have a strong background in glycobiology and refine the glycomics workflow according to our clients' needs.
- Relying on a huge database and advanced computational tools, we provide custom analytical model construction and optimization services for our clients.
Frequently Asked Questions
- What is malaria and how is it transmitted?
- Malaria is an acute febrile illness caused by the Plasmodium parasite. It is preventable and curable. Malaria is not transmitted from person to person, but mainly through the bite of mosquitoes, especially Plasmodium falciparum and Plasmodium vivax.
- Can clients directly use the data reports obtained from glycomics analysis?
- Sure! Our computing team organizes all the data, categorizes it, and provides visual data presentations for direct use by our clients.
By utilizing advanced computational methods, CD BioGlyco provides our clients with easy access to malaria glycomics analysis. We combine the analytical strengths of different disciplines to provide the most satisfying solutions for our clients. Please feel free to contact us.
Reference
- Day, C.J.; et al. The essential malaria protein PfCyRPA targets glycans to invade erythrocytes. Cell Reports. 2024, 43(4).
For research use only. Not intended for any diagnostic use.
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