Employing computational models, software tools, and mass spectrometry data analysis techniques, CD BioGlyco provides the glycoinformatics-assisted glycan biosynthesis pathway analysis service based on our Glycan-related Transcriptomics Analysis. Using multiple glycosylation pathways provided by computational models to predict changes in structures possible due to a mutation, and theoretical structural estimates, while mass spectrometry ensures both accuracy and comprehensiveness concentrations.
Fig.1 Main mammalian types of glycosylation. (Scheper, et al., 2023)
Moreover, CD BioGlyco is also supported by multiple databases for performance, among which include the UniCarbKB, KEGG GLYCAN, as well as the Glycoepitope databases. While the UniCarbKB contains about 3000 N-glycan structures and offers abundant experimental data and literature support, the KEGG GLYCAN displays all carbohydrate structures in a tree form presenting a comprehensive overview of the sources of the molecules and related Glycosyltransferase information and the Glycoepitope database involves the description of a group of oligosaccharides with specific structural features and also supports accurate glycosylation pathway prediction. The support of these technologies and databases makes it possible for CD BioGlyco to offer comprehensive and accurate glycosylation analysis services that will enable glycobiology to conduct groundbreaking research and exploration. Additionally, we also provide other advanced Glycoinformatics-assisted Glycomics Analysis Services for our clients to help their research.
CD BioGlyco supports comprehensive glycan profiling by combining computational models, software tools, and mass spectrometry data. It has been used to prepare for structural changes that may result from mutations and also how explicit data that comes with a mass spectrometry experiment can be comprehensive.
Our service is supported through robust databases like UniCarbKB having almost 3000 N-glycan structures, KEGG GLYCAN which provides a global picture of carbohydrate structure and the associated glycosyltransferase information, Glycoepitope support to precise glycocoding pathway predictions.
Accurate predictions of difficult-to-identify glycan structures make our clients run their Band 7 with a rich set of experimental data for cutting-edge glycobiology research. This full service works for the discovery of novel glycosylation pathways among many others that drive a better comprehension in terms of molecular mechanisms associated with function.
DOI: 10.1016/j.arr.2023.101991
Technology: Glycan release and derivatization, Exoglycosidase digestion, MS fragmentation analysis, LC-MS, MALDI MS
Journal: Ageing Research Reviews
Published: 2023
IF: 12.5
Results: The article explores the role of glycosylation, particularly N- and O-glycosylation, in brain proteins and its implications for neurodegenerative diseases. It highlights the importance of advanced glycomics and glycoproteomics technologies in identifying glycan profiles in brain tissues and cerebrospinal fluid (CSF). The study compiled glycan data from healthy and neurodegenerative conditions into the GlyConnect database. The research underscores the potential of glycosylation patterns as biomarkers for neurodegeneration, offering new therapeutic targets and diagnostic tools to understand and monitor disease mechanisms.
Fig.2 Selected glycans detected in the brain and CSF. (Costa, et al., 2023)
At CD BioGlyco, our glycoinformatics-assisted glycan biosynthesis pathway analysis service offers unparalleled accuracy and depth in glycan structure analysis by integrating cutting-edge computational models, advanced software tools, and precise mass spectrometry techniques. Please feel free to contact us for more details if you are interested in our service!
References
We envision a future where the intricate world of carbohydrate is no longer shrouded in mystery, but rather illuminated by the power of cutting-edge computational tools.