Glycoinformatics-assisted Glycan Biosynthesis Pathway Analysis Service

Glycoinformatics-assisted Glycan Biosynthesis Pathway Analysis Service

Comprehensive Glycosylation Analysis Service Utilizing Advanced Techniques and Databases

Employing computational models, software tools, and mass spectrometry data analysis techniques, CD BioGlyco provides the glycoinformatics-assisted glycan biosynthesis pathway analysis service based on our Glycan-related Transcriptomics Analysis. Using multiple glycosylation pathways provided by computational models to predict changes in structures possible due to a mutation, and theoretical structural estimates, while mass spectrometry ensures both accuracy and comprehensiveness concentrations.

Fig.1 Main mammalian types of glycosylation.Fig.1 Main mammalian types of glycosylation. (Scheper, et al., 2023)

Moreover, CD BioGlyco is also supported by multiple databases for performance, among which include the UniCarbKB, KEGG GLYCAN, as well as the Glycoepitope databases. While the UniCarbKB contains about 3000 N-glycan structures and offers abundant experimental data and literature support, the KEGG GLYCAN displays all carbohydrate structures in a tree form presenting a comprehensive overview of the sources of the molecules and related Glycosyltransferase information and the Glycoepitope database involves the description of a group of oligosaccharides with specific structural features and also supports accurate glycosylation pathway prediction. The support of these technologies and databases makes it possible for CD BioGlyco to offer comprehensive and accurate glycosylation analysis services that will enable glycobiology to conduct groundbreaking research and exploration. Additionally, we also provide other advanced Glycoinformatics-assisted Glycomics Analysis Services for our clients to help their research.

Client benefits of CD BioGlyco's glycoinformatics-assisted glycan biosynthesis pathway analysis service. (CD BioGlyco)

Custom comprehensive analysis

CD BioGlyco supports comprehensive glycan profiling by combining computational models, software tools, and mass spectrometry data. It has been used to prepare for structural changes that may result from mutations and also how explicit data that comes with a mass spectrometry experiment can be comprehensive.

Robust databases support

Our service is supported through robust databases like UniCarbKB having almost 3000 N-glycan structures, KEGG GLYCAN which provides a global picture of carbohydrate structure and the associated glycosyltransferase information, Glycoepitope support to precise glycocoding pathway predictions.

Enhanced research capabilities

Accurate predictions of difficult-to-identify glycan structures make our clients run their Band 7 with a rich set of experimental data for cutting-edge glycobiology research. This full service works for the discovery of novel glycosylation pathways among many others that drive a better comprehension in terms of molecular mechanisms associated with function.

Publication

DOI: 10.1016/j.arr.2023.101991

Technology: Glycan release and derivatization, Exoglycosidase digestion, MS fragmentation analysis, LC-MS, MALDI MS

Journal: Ageing Research Reviews

Published: 2023

IF: 12.5

Results: The article explores the role of glycosylation, particularly N- and O-glycosylation, in brain proteins and its implications for neurodegenerative diseases. It highlights the importance of advanced glycomics and glycoproteomics technologies in identifying glycan profiles in brain tissues and cerebrospinal fluid (CSF). The study compiled glycan data from healthy and neurodegenerative conditions into the GlyConnect database. The research underscores the potential of glycosylation patterns as biomarkers for neurodegeneration, offering new therapeutic targets and diagnostic tools to understand and monitor disease mechanisms.

Fig.2 These glycans from the brain and CSF.Fig.2 Selected glycans detected in the brain and CSF. (Costa, et al., 2023)

Frequently Asked Questions (FAQs)

  • How does CD BioGlyco's glycan biosynthesis pathway analysis service benefit researchers in glycobiology?
    • Our service uses computational models and mass spectrometry to produce very accurate results. With the strength of well-established databases like UniCarbKB and KEGG GLYCAN which contain comprehensive experimental data as well as literature, researchers can discover new glycosylation pathways with ease, comprehend heterogeneous/glycan structure easily, and fuel their glycobiology research.
  • What is the Glycoinformatics-assisted Glycan Biosynthesis Pathway Analysis Service offered by CD BioGlyco?
    • Our service is based on computational approaches and mass spectrometry and also aids in the analysis and inference of glycan structures. The integration enables researchers to study glycosylation pathways, predict the impact of mutation-induced changes at a structural level, and unlock unprecedented molecular biology in glycobiology.

Applications

  • The glycoinformatics-assisted glycan biosynthesis pathway analysis can be used to help identify glycan structures critical for disease processes, aiding in the development of novel therapeutic targets.
  • The glycoinformatics-assisted glycan biosynthesis pathway analysis can be used to identify specific glycan structures as biomarkers for early disease detection and prognosis.
  • This analysis technology can be used to study interactions between glycan structures and proteins, elucidating their role in cell signaling and immune responses.

Advantages

  • Our service integrates advanced computational models, software tools, and mass spectrometry to provide a thorough analysis of glycan structures.
  • We utilize extensive databases like UniCarbKB, KEGG GLYCAN, and Glycoepitope to ensure precise predictions and comprehensive results.
  • We tailor analysis based on specific research needs, including drug development and functional glycomics.
  • We are backed by rich experimental data and literature, providing a robust foundation for your glycosylation research.

At CD BioGlyco, our glycoinformatics-assisted glycan biosynthesis pathway analysis service offers unparalleled accuracy and depth in glycan structure analysis by integrating cutting-edge computational models, advanced software tools, and precise mass spectrometry techniques. Please feel free to contact us for more details if you are interested in our service!

References

  1. Scheper, A.F.; et al. Understanding glycosylation: Regulation through the metabolic flux of precursor pathways. Biotechnology Advances. 2023, 67: 108184.
  2. Costa, J.; et al. Protein glycosylation and glycoinformatics for novel biomarker discovery in neurodegenerative diseases. Ageing research reviews. 2023, 89: 101991.
For research use only. Not intended for any diagnostic use.
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We envision a future where the intricate world of carbohydrate is no longer shrouded in mystery, but rather illuminated by the power of cutting-edge computational tools.

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