Glycoinformatics-assisted Glycan 3D Structure Image

Glycoinformatics-assisted Glycan 3D Structure Image

Unveiling the Structure of Glycans with 3D Structure Image

Glycans are a class of bioactive molecules widely found in nature, which present a wealth of biological functions due to their structural diversity. To fully characterize the biological functions of glycans, it is necessary to explore their structures in depth. Therefore, Analyzing Glycan Structures is one of the most common tasks performed by glycobiologists. At CD BioGlyco, we integrate advanced glycoinformatics technologies to Interpret and Visualize Glycan Structures, providing our clients with a full range of glycan three-dimensional (3D) structure imaging services.

Glycan structure visualization

We use the core N- and O-linked glycans as a native database to provide templates for displaying more complex glycan molecules. The database allows the registration of a wide range of structures from monosaccharide compositions to fully defined glycans, and displays glycan structures based on the concept of oligosaccharide schematics.

In the drawing of glycan structures, bonds of different lengths and widths represent different glycosidic bonds. We provide maximum flexibility to display glycans in any desired or necessary form, size, and orientation. The native database we construct assigns a unique ordinal number to any glycan to identify its structure and displays information about the structure and motifs of the glycan.

Glycan 3D structure imaging

We provide tools for displaying glycan structures that allow rapid construction of glycans, and the obtained glycan 3D structures are presented in image format. In addition, our tool automatically detects information about glycan molecules and glycosidic bonds by reading glycan data, sampling glycosidic bonds, ring forms, and side chain conformations, and searching through a database of glycan fragments to generate the "most relevant" glycan 3D structure.

On the other hand, we have a glycan structure imaging tool that provides 3D structural characterization of glycans. We integrate it with various glycoinformatics software to distort and change the orientation of subsequent glycan residues according to their relative positions, thus providing important conformational details in the glycan.

Our glycan 3D structure imaging service. (CD BioGlyco)

Publication Data

Technology: Glycoinformatics technology

Journal: Beilstein Journal of Organic Chemistry

IF: 2.2

Published: 2020

Results: In this article, the authors describe 3D-Symbol Nomenclature for Glycans-Visual Molecular Dynamics (3D-SNFG-VMD), a tool for drawing 3D structures of glycans. 3D-SNFG-VMD integrates VMD data to display 3D structures of glycans. The integrated script in VMD automatically recognizes the names of common monosaccharides and generates 3D shapes when a glycan-containing structure is entered. The glycan 3D structure displayed in VMD can also be saved as a .bmp image file.

Applications

  • In the field of drug R&D, glycan 3D structure images can help researchers design and develop more effective drugs, especially for the treatment of glycan-related diseases.
  • In the field of biofuels, glycan 3D structure images can help improve the utilization of biomass and increase the efficiency and quality of biofuel production.
  • The glycan 3D structure image helps researchers understand the association between specific diseases and glycan structures, thus providing deeper insights into the diagnosis and treatment of diseases.

Advantages

  • Professional team: We have professional team members, including chemical experts, bioinformaticians software engineers, etc., and have rich experience and knowledge accumulation in the field of glycans, which enables us to provide a full range of glycan 3D structure imaging services.
  • Advanced technology: We have advanced glycan informatics software and tools, which allow us to realize accurate imaging of glycan 3D structures through advanced algorithms and data processing techniques.
  • Customized solutions: We customize solutions to meet the needs of glycan 3D structure imaging in different fields and industries.

Frequently Asked Questions

  • What are the key technologies and methods to facilitate glycan 3D structure imaging?
    • Molecular modeling: Structural modeling of glycan molecules using computational methods to determine their spatial configuration and interatomic interactions.
    • Visualization tool development: Development of tools and software for visualizing glycan structures, dynamic behaviors, and interactions.
    • Image processing and rendering: Image processing and rendering techniques are used to visually present the molecular structure and dynamic behavior for more intuitive understanding and analysis by the user.
  • How can glycan 3D structure imaging be utilized to understand biomolecular interaction mechanisms?
    • Glycan 3D structure imaging can visualize the structure and spatial conformation of glycan molecules, which helps researchers to understand their specific morphology and conformation in organisms, as well as the interaction mechanism between glycans and other molecules (e.g., proteins, cell membranes, etc.) in organisms, to thoroughly research their biological activities and biological functions in organisms.

CD BioGlyco utilizes key technologies and methods in the field of glycoinformatics to perform accurate glycan 3D structure imaging. We help researchers research and explore glycan structure and function through glycan 3D structure imaging, and promote our clients' in-depth understanding of the interaction mechanisms between glycans and other biomolecules. Please feel free to contact us if you are looking for a partner in glycan structure analysis.

Reference

  1. Lal, K.; et al. Computational tools for drawing, building and displaying carbohydrates: a visual guide. Beilstein J. Org. Chem. 2020, 16: 2448-2468.
For research use only. Not intended for any diagnostic use.
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We envision a future where the intricate world of carbohydrate is no longer shrouded in mystery, but rather illuminated by the power of cutting-edge computational tools.

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