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In a comprehensive 2020 review published in the Israel Journal of Chemistry, Dillon T. Flood and colleagues provided an essential roadmap for the field with their article, "DNA encoded libraries: a visitor's guide." This work systematically synthesizes the vast landscape of DEL technology, from its conceptual origins to contemporary advances in synthesis and screening methodologies. […]

In a pivotal 2016 study published in MedChemComm, Oliv Eidam and Alexander L. Satz delivered a critical analysis titled "Analysis of the productivity of DNA encoded libraries," systematically evaluating the physical properties, novelty, and hit rates of compounds derived from DNA-encoded library (DEL) screens. Their work established that DEL productivity is driven not by sheer […]

In a landmark 2009 publication in Nature Chemical Biology, a research team led by M.A. Clark unveiled a pioneering strategy titled "Design, synthesis and selection of DNA-encoded small-molecule libraries." This seminal work established the fundamental blueprint for DNA-encoded library (DEL) technology, demonstrating for the first time the high-throughput synthesis and screening of hundreds of millions […]

On June 19, 2015, a landmark study by Alexander Lee Satz and colleagues at Roche, titled "DNA compatible multistep synthesis and applications to DNA encoded libraries," was published in Bioconjugate Chemistry. This work provided the first comprehensive toolkit of robust, multi-step chemical reactions meticulously optimized for the challenging environment of DNA-encoded library (DEL) synthesis. Through […]

On Nov 14, 2011, the article "DNA-encoded chemical libraries: 20 years of revolutionizing drug discovery" provides a comprehensive review of the evolution and impact of DNA-encoded library (DEL) technology over the past two decades. Originally conceptualized in 1992 by Brenner and Lerner, DELs have matured from a theoretical framework into a powerful platform that integrates […]

On June 14, 2021, the article "DNA-encoded chemical libraries: a comprehensive review with successful stories and future challenges" provides a comprehensive examination of the groundbreaking review "DNA-encoded chemical libraries: a comprehensive review with successful stories and future challenges" by Gironda-Martinez et al., published in ACS Pharmacology & Translational Science. This influential analysis traces the remarkable […]

In the influential paper "DNA encoded library selections and insights provided by computational simulations" by Alexander L. Satz, published in ACS Chemical Biology, the author addresses this challenge through a mathematical model that simulates DEL selections, revealing how factors like protein concentration and synthetic yield affect enrichment counts. This research critiques the assumption that higher […]

On June 03, 2025, a groundbreaking study titled "Native mass spectrometry facilitates hit validation in DNA-encoded library technology" was published in Angewandte Chemie International Edition by Bittner and colleagues. This research introduces native mass spectrometry (MS) as a transformative solution for addressing critical bottlenecks in DEL hit validation, demonstrating for the first time a methodology […]

On March 18, 2019, a groundbreaking study by Cochrane et al. published in ACS Combinatorial Science introduced activity-based DNA-encoded library (DEL) screening as a transformative paradigm shift in drug discovery. This research addressed key limitations of traditional affinity-based DEL methods by developing an integrated microfluidic platform that enables functional screening of complex targets like ion […]