Design & Encoding

December 18, 2025

In a landmark 2009 publication in Nature Chemical Biology, a research team led by M.A. Clark unveiled a pioneering strategy titled "Design, synthesis and selection of DNA-encoded small-molecule libraries." This seminal work established the fundamental blueprint for DNA-encoded library (DEL) technology, demonstrating for the first time the high-throughput synthesis and screening of hundreds of millions […]

October 8, 2025

On July 29, 2025, a transformative study by Tse et al. in RSC Med. Chem. demonstrated how accessible DNA-encoded library (DEL) technology expands research possibilities by overcoming historical barriers. Using simple amide coupling chemistry and commercially available building blocks like Fmoc-amino acids, the team constructed a diverse 3-million-compound DEL with minimal resources, achieving 89% DNA […]