Synthesis

December 18, 2025

In a comprehensive 2020 review published in the Israel Journal of Chemistry, Dillon T. Flood and colleagues provided an essential roadmap for the field with their article, "DNA encoded libraries: a visitor's guide." This work systematically synthesizes the vast landscape of DEL technology, from its conceptual origins to contemporary advances in synthesis and screening methodologies. […]

October 6, 2025

On September 28, 2025, a pioneering study by Miyachi et al. published in the International Journal of Molecular Sciences introduced a transformative diazide platform molecule (DAP) designed to overcome critical limitations in DNA-encoded library (DEL) technology. This research addresses the constrained chemical space of traditional DELs, which often rely on limited reaction sets like CuAAC, […]