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Native MS: A Breakthrough in DEL Hit Validation

Hit Validation

Native MS: A Breakthrough in DEL Hit Validation
November 18, 2025
Native MS: A Breakthrough in DEL Hit Validation

On June 03, 2025, a groundbreaking study titled "Native mass spectrometry facilitates hit validation in DNA-encoded library technology" was published in Angewandte Chemie International Edition by Bittner and colleagues. This research introduces native mass spectrometry (MS) as a transformative solution for addressing critical bottlenecks in DEL hit validation, demonstrating for the first time a methodology […]

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