Hit Validation

April 8, 2026

In the rapidly evolving field of drug discovery, DNA-encoded chemical libraries (DECLs) have emerged as a powerful tool for high-throughput screening of vast compound collections. The recent study by Zimmermann et al., published in ChemBioChem, titled "Hit validation methodologies for ligands isolated from DNA-encoded chemical libraries," presents groundbreaking approaches to streamline the validation of hits […]

November 18, 2025

On June 03, 2025, a groundbreaking study titled "Native mass spectrometry facilitates hit validation in DNA-encoded library technology" was published in Angewandte Chemie International Edition by Bittner and colleagues. This research introduces native mass spectrometry (MS) as a transformative solution for addressing critical bottlenecks in DEL hit validation, demonstrating for the first time a methodology […]