Screening

December 18, 2025

In a pivotal 2016 study published in MedChemComm, Oliv Eidam and Alexander L. Satz delivered a critical analysis titled "Analysis of the productivity of DNA encoded libraries," systematically evaluating the physical properties, novelty, and hit rates of compounds derived from DNA-encoded library (DEL) screens. Their work established that DEL productivity is driven not by sheer […]

October 18, 2025

On March 18, 2019, a groundbreaking study by Cochrane et al. published in ACS Combinatorial Science introduced activity-based DNA-encoded library (DEL) screening as a transformative paradigm shift in drug discovery. This research addressed key limitations of traditional affinity-based DEL methods by developing an integrated microfluidic platform that enables functional screening of complex targets like ion […]