Analyze Cancer Glycosylation Changes Precisely with Glycoinformatics!

At CD BioGlyco, we continue to promote the integration and innovation of glycobiology and information technology. Starting from the basic Glycoinformatics-assisted Glycomics Analysis Services, we gradually deepen our service areas. First, we expand to a wider range of disease research and provide Glycoinformatics-assisted Disease Glycomics Analysis Service, which aims to comprehensively analyze the dynamic changes of glycomics in disease states. Then, we specially create Glycoinformatics-assisted Cancer Glycomics Analysis Services, which focuses on cancer-related glycomics research.

Here, we proudly offer analysis of glycosylation changes in cancer, which uses our glycoinformatics platform, combined with high-precision mass spectrometry (MS) technology, to deeply explore and analyze the subtle details of glycosylation changes during the development of cancer.

Sample preparation and analysis

We begin by obtaining high-quality biological samples from clients, which may include tissue, blood samples, or cultured cells. Our experienced team employs advanced techniques such as MS and liquid chromatography (LC) to accurately identify and quantify glycan structures.

Glycan characterization

Using our glycan profiling techniques, we comprehensively characterize the glycan structures present in the samples. This includes identifying the monosaccharide composition, glycosidic linkages, branching patterns, and any modifications like sialylation, fucosylation, or sulfation.

Glycoinformatics analysis

Our specialized glycoinformatics platform integrates high-throughput data analysis with curated glycan databases. This involves:

Data integration: Aggregating and normalizing data from various high-throughput platforms, ensuring consistency and accuracy.

Pathway mapping: Mapping glycosylation changes onto known metabolic and signaling pathways to decipher their biological significance.

Comparative glycomics

To identify cancer-specific glycosylation changes, we perform comparative glycomics by contrasting the glycan profiles of cancerous samples with normal or benign tissues. This differential analysis highlights unique glycosylation signatures that may serve as potential biomarkers for cancer detection and prognosis.

Functional impact assessment

We explore the functional implications of identified glycosylation changes. This includes:

Assessing the impact on protein folding, stability, and interactions.

Evaluating the potential for immune system evasion via altered glycan motifs.

Investigating any influence on cell signaling pathways and adhesion properties.

Custom reporting and consultation

Our final step involves delivering a comprehensive report that includes detailed glycan structures, statistical analyses, pathway implications, and potential biomarkers. We also offer personalized consultation sessions to discuss findings and recommend further experimental validation or therapeutic exploration.

Publication Data

Applications

• This analytical technique can be used to systematically analyze the differences in glycan structures between cancer cells and normal cells. This helps reveal specific patterns of changes in glycan synthesis and modification during cancer development.
• This analytical technique can be used to predict interactions between glycans and proteins, especially those that change in cancer. These predictions can be verified experimentally to reveal how glycans affect protein activity, stability, and function.
• This analytical technique can be used to dig deeper into the details of abnormal glycosylation pathways in cancer, including changes in the expression of key enzymes, substrate specificity, and accumulation of metabolites. This helps to elucidate the specific mechanisms of action of glycans in cancer occurrence and development.

Advantages of Us

• Our services provide unprecedented data depth and precision by deeply analyzing the subtle changes in glycan structures during cancer development.
• Our services use advanced glycoinformatics tools to quickly predict the interactions between glycans and biological molecules and verify these predictions through experiments. This capability accelerates our understanding of cancer-related biological processes.
• Our services cover a wide range of glycosylation pathway analysis, from gene expression to enzymatic reactions to the formation of final products, revealing the dynamic changes of glycosylation in cancer from all aspects.

Frequently Asked Questions

• What is the role of glycoinformatics in the analysis of changes in cancer glycosylation?
  • Glycoinformatics is a field that crosses glycomics and bioinformatics, focusing on the study of the molecular structure, function, and combination of carbohydrate substances with bioinformatics. In the analysis of changes in cancer glycosylation, Glycoinformatics uses advanced bioinformatics tools and technologies such as MS data analysis, genomics, and transcriptomics to analyze the changes in glycosylation patterns in cancer cells. These changes are crucial to understanding the mechanisms of cancer occurrence, development, and metastasis, and provide an important basis for early diagnosis of cancer, discovery of therapeutic targets, and personalized medicine.
• Why choose your service instead of direct MS analysis?
  • Although direct MS analysis can obtain the raw data of glycan chains, it lacks professional glycoinformatics support, and is difficult to fully analyze the structural and functional information of glycan chains. Our service not only provides high-quality MS analysis but also combines professional glycoinformatics analysis to deeply explore the biological significance behind the data. In addition, our expert team has a rich knowledge of glycobiology and bioinformatics and provides clients with more comprehensive and professional interpretations and suggestions.

At CD BioGlyco, we are dedicated to advancing cancer research through innovative glycomic solutions. Our analysis of glycosylation changes in cancer offers unparalleled precision and insight into the complex world of cancer glycosylation. Please feel free to contact us if you are interested in our analysis of glycosylation changes in cancer.

• Analysis of Glycans on Specific Glycoproteins
• Comparative Glycoproteomics of Serum
• Analysis of Glycoprotein Expression Changes in Cancer
• Analysis of O-Linked Glycans in Cancer
• Comparative Glycoproteomic Analysis in Cancer
• Detection of Glycan Variation on Glycoprotein Markers