It is well known that α-glucan plays an important role as a modulator of immune responses. Studies have demonstrated the potential of α-glucan as an adjuvant and carrier for cancer immunotherapy. CD BioGlyco is a leader in carbohydrate adjuvant development and has established an advanced Glyco™ Vaccine Development Platform. Our adjuvant development services have been recognized by researchers from many countries. We are confident to be your indispensable assistant in α-glucan-based adjuvant development.
α-Glucan is a homopolysaccharide composed of glucose monomers linked by α-glycosidic bonds. The most common α-glucans are α-1,3 glucans, α-1,4 glucans, and α-1,6 glucans. Despite extensive research on microbial glucans, reports on α-glucan adjuvants are still rare, mainly focusing on modified dextran and starches. Dextran is a microbial polysaccharide composed of α-1,6-glucans and α-1,3-branched chains, with various human therapeutic applications, such as antithrombotic agents. Studies have shown the potential of diethylaminoethyl (DEAE)-dextran in enhancing antibodies to the whole-cell cholera vaccine in mice.
Dextran activates NF-κB and induces pro-inflammatory responses, such as sulfated dextran-induced inflammatory colitis in mice. DEAE-dextran, a polycationic derivative of dextran used in veterinary adjuvants, enhanced primary immune responses to Venezuelan equine encephalomyelitis virus vaccine in rhesus monkeys and enhanced antibody responses to whole-cell cholera vaccine in mice. In a mouse model, a dextran-cytosine-phosphate-guanine (CpG) adjuvant conjugate enhanced cytotoxic T lymphocytes and tumor-specific Th1 immune responses to protein vaccines. This demonstrates the potential of dextran adjuvants in cancer immunotherapy. In addition, acetylated dextran particles were used as antibody-adjuvant carriers to deliver the Toll-like receptor 7 (TLR-7) agonist imiquimod to immune cells, enhancing the body's humoral and cellular immunity.
Fig.1 Dextran-CpG adjuvant enhances anti-tumor immunotherapy. (Zhang, 2017)
Compounds derived from plants and natural products have great advantages in immunomodulation. Among polysaccharides, α-glucan has attracted much attention. CD BioGlyco provides customers with plant-derived α-glucan adjuvants development services. Our services include but are not limited to:
CD BioGlyco has been focusing on the development of carbohydrate adjuvants for many years. Our experts are pleased to provide α-glucan-based adjuvant development services according to your needs. If you currently have special needs in α-glucan adjuvant development, please contact us directly, and we will do our best to help you with your project.