CD BioGlyco has successfully developed many Glycobiology Arrays and corresponding testing services to accelerate the high-throughput detection of glycosylated proteins in biological samples. Glycan modification array is one of them. We guarantee to provide first-class array screening service to customers all over the world.
Glycosylation is a common post-translational modification (PTM) of proteins. This feature is caused by changes in sequence and chain length, anomeric configuration (α or β), connection positions, and branch sites. The covalent modification of a single glycan residue through sulfation, phosphorylation, acetylation or methylation adds further structural variation to the carbohydrate chain. Therefore, the structural diversity available in glycan chains far exceeds the complexity of obtaining amino acids in polypeptides. Two of the most abundant forms of protein glycosylation are N- and O-linked glycosylation. N-linked glycans are usually linked to asparagine (Asn) via GlcNAc. Mucin-type O-linked glycans are linked to Ser or Thr via GalNAc, but other O-glycans can be linked to Ser/Thr via GlcNAc, fucose, glucose, or mannose.
The glycan-modified microarrays provided by CD BioGlyco can be used in a variety of analyses. These arrays can be used to determine the presence of modifications and quantify them. Using our glycan modification array for the analysis of N-glycan and O-glycan profiles in biological samples will speed up the analysis of sugar floors. Sias are acid sugars that cover the glycoproteins and glycolipids on the surface of vertebrate cells. Non-human Sia is dangerous to enter the human body. The glycocalyx of human cells is different from that of many other mammals in that it lacks the sialic acid N-hydroxymethylneuraminic acid (Neu5Gc), and the abundance of its precursor hydroxylated form N-acetylneuraminic acid (Neu5Ac) is increased. Neu5Gc is recognized as a foreign body by the human body's fluid immune system. This is especially important when using non-human cells to produce antibodies. These modifications have a huge impact on the structure and function of glycoproteins. Microarray tools have far-reaching significance for rapid analysis and detection of these modifications and analysis of glycoproteins.
CD BioGlyco provides high-quality array screening services for the rapid detection of glycosylated proteins. We provide commercialized arrays and customized array services for glycomics analysis according to your research goals. With a large team of scientists and a well-equipped array production platform and testing experiment platform, we offer a comprehensive combination of laboratories and manufacturing services. We have comprehensive capabilities and are committed to working with customers all over the world to meet your specific requirements. Please contact us for more details.
|Cat. No.||Product Name||Inquiry|
|CMA-NEU-1||Neu5Gc/ Neu5Ac Glycan Array|