The pentose phosphate pathway consists of two branches. The oxidative branch has three irreversible reactions producing NADPH and ribonucleotides. The non-oxidative branch consists of a series of reversible reactions that recruit glycolytic metabolic intermediates. A growing number of studies have shown a strong link between the pentose phosphate pathway and the malignant progression of cancer cells. The activity of pentose phosphate pathway-related enzymes regulates the rate of the pentose phosphate pathway. Therefore, it is important to understand the activities of pentose phosphate pathway-related enzymes and how they are regulated. CD BioGlyco can provide the expression analysis, activity analysis, and regulatory mechanism analysis of pentose phosphate pathway-related enzymes based on proteomics technology.
Fig. 1 Schematic representation of pentose phosphate pathway (Cai Y, et al., 2019)
Based on the MOPCGM platform, we can provide the following services.
We can provide the following PPP related enzymes expression assays.
Different types of post-translational modifications in the pentose phosphate pathway regulate the activities of metabolic enzymes, provide macromolecular raw materials for the growth and proliferation of cancer cells, and affect the proliferation of cancer cells.
We can provide the following post-translational modifications of PPP related enzymes, including but not limited to:
PPP related enzymes can form complexes with other proteins and regulate the functions of these proteins through metabolites.
We can provide the following interaction analysis of the PPP related enzymes, including but not limited to:
Our services can support the following applications, including but not limited to:
CD BioGlyco provides analysis services for the expression, post-translational modification, activity, and interaction mechanism of the pentose phosphate pathway related enzymes. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.