18F-FDG-PET/CT technology combines anatomical image CT and functional metabolic image PET, which can detect the initial state of the tumor before the clinical symptoms or anatomical structure changes of the tumor, and can be used in clinical early diagnosis. Whole-body 18F-FDG-PET/CT in tumor-bearing mice can detect glucose uptake in specific tissues in real-time, which is of great significance for the study of cancer tissue glucose metabolism. Micro-PET is a small and high-resolution positron emission tomography imaging technology. It has the advantages of fast imaging speed, high sensitivity, and small toxic and side effects. It can be applied to in vivo imaging of tumor-bearing mice to study the metabolic status of tumor-bearing mice. CD BioGlyco provides whole-body 18F-FDG PET/CT and micro-PET/CT imaging assays of tumor-bearing mice.
The radiotracer 18F-FDG has homolog properties of glucose, and FDG exhibits greater specificity in assessing aggressive glycolytic cancers. After 18F-FDG enters the cells, 6-P-18F-FDG cannot be further metabolized and stays in the cancer cells, so the uptake of 18F-FDG is proportional to the metabolic rate of glucose. For cancer cells, the up-regulation of transporters on the cancer cell membrane and the increased activity of hexokinase in cancer cells are all associated with the accumulation of 18F-FDG. For rodents, the resolution of PET/CT technology is poor. Micro-PET/CT can be applied to in vivo imaging of small rodents, which can dynamically monitor the distribution changes of 18F-FDG in mice in real-time.
Fig. 1 FDG-6P is trapped within the cancer cell (Plöckinger U, et al., 2018)
These assays provide a whole-body metabolism image of tumor-bearing mice, distribution, and metabolism of 18F-FDG in various tissues of mice.
CD BioGlyco provides whole-body 18F-FDG PET/CT and micro-PET/CT imaging assays of tumor-bearing mice. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.