Monoacylglycerols (MAGs) are a class of glycerides that play a huge role in the food and cosmetics industry. CD BioGlyco is a leader in the field of Lipid Analysis and has extensive analysis experience. We provide customers with a variety of lipid analysis methods, such as gas chromatography-mass spectrometry (GC-MS), MS/MS^ALL. Welcome to cooperate with us!

Introduction of MAG

MAGs are a class of glycerides, which are formed by the esterification of hydroxyl groups in glycerol molecules with fatty acids (FAs). Since glycerol contains primary and secondary alcohol groups, MAGs are divided into 1-MAG (FA is linked to primary alcohol) and 2-MAG (FA is linked to secondary alcohol). MAGs in organisms are used as intermediates in the process of fat production or produced by the hydrolysis of fats.

Fig.1 Biological pathways of MAGs. (Gao, 2016)

In organisms, MAGs are vital structural and active metabolites, which play roles in lipid metabolism and homeostasis. MAGs are located in the center of lipid pathways and control the flow and distribution of FAs to other complex lipids. In biological systems, the level of MAGs is regulated by a variety of enzymes, such as monoacylglycerol lipase (MAGL). The destruction of MAGL may disturb the balance of MAGs. MAGs are widely used as an emulsifier in the food and cosmetic industries to prevent the separation of oil and water mixtures. In addition, MAGs are used as a fresh-keeping agent to improve the volume and texture of the bread. MAGs are also be used to improve the physical stability of creaming in milk beverages.

Fig.2 Applications of MAGL inhibitors. (Gil-Ordóñez, 2018)

Services

MAGs are essential for lipid metabolism and homeostasis. Meanwhile, MAGs also occupy an important role in the food and cosmetics industry. Therefore, it is necessary to carry out a quantitative analysis of MAGs. CD BioGlyco analysis methods of MAGs include but are not limited to:

• GC-MS

  As an important tool for lipid analysis, GC-MS has good separation efficiency and is relatively economical. GC-MS are used to identify MAG regio-isomers and analyze MAG in human plasma and organ tissues.

• MS/MS^ALL

  The independent data acquisition method using electrospray ionization (ESI) coupled with quadrupole time-of-flight MS is suitable for the structure identification and quantitative analysis of a single MAG molecule.

Advantages of Us

• Handling different types of samples
• Multiple analysis methods
• Complete analysis report
• 24 hours after-sales service

CD BioGlyco provides a systematic one-stop service for the structure identification and quantitative analysis of MAGs. Ensure strict experimental procedures and reliable analysis reports. If you are interested in our services, please feel free to contact us.

References:

1. Gao, F.; et al. Monoacylglycerol analysis using MS/MS^ALL quadruple time of flight mass spectrometry. Metabolites. 2016, 6(3): 25.
2. Gil-Ordóñez, A.; et al. Monoacylglycerol lipase (MAGL) as a promising therapeutic target. Biochemical Pharmacology. 2018, 157: 18-32.