Custom Glycosylation Service
Glycosylation plays an important role in a variety of biological processes. Studies have shown that abnormal glycosylation is closely related to the occurrence and development of many diseases. Therefore, scientists are paying more and more attention to glycosylation research. Scientists at CD BioGlyco are experienced in performing custom glycosylation of protein, antibody, cell membrane, and bacterial membrane and we can provide custom glycosylation services according to your specific needs.
What Is Glycosylation?
Glycosylation is the process of adding carbohydrates to proteins or lipids under the control of enzymes in the endoplasmic reticulum (ER) and Golgi apparatus and is one of the most common post-translational modifications. Proteins are glycosylated to form glycoproteins, which are involved in almost all innate and adaptive immune responses. Protein glycosylation mainly includes the addition of N-glycans, O-glycans, glycosylphosphatidylinositol (GPI) anchors, and phosphorylated glycans to the peptide backbones. Sugars are added to lipids to form glycolipids, such as glycosphingolipids (GSLs). GSLs are among the most abundant glycolipids in humans, performing key cellular functions associated with lipid rafts, and their glycan composition confers specific GSL properties.
Fig.1 The types of glycosylation. (Reily, 2019)
Glycosylation in Disease
Glycosylation patterns are one of the first biomarkers of cancer to identify cells with a stem cell-like phenotype in cancer. Glycosylation of specific proteins in serum and tumors is used to assess patient efficacy and prognostic response, such as MUC1 and prostate-specific antigen (PSA). Changes in fucosylation, sialylation, and galactosylation may contribute to autoimmune disease and chronic inflammation. Currently, developments in the field of glycobiology have enabled the development of various glycan-based therapeutics. For example, increased Fc galactosylation in rituximab enhanced complement-dependent cytotoxicity. Therefore, glycosylation services have become an essential part of glycobiology.
Our Glycosylation Services
CD BioGlyco has been committed to research in the field of glycosylation for many years. We provide our customers with high-quality, cost-effective, and hassle-free customized glycosylation services. If you are interested in our services, please feel free to contact us, we are looking forward to being your indispensable assistant in the glycosylation field.
References:
- Reily, C.; et al. Glycosylation in health and disease. Nature Reviews Nephrology. 2019, 15(6): 346-366.
- Van Erp, E.A.; et al. Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease. Frontiers in immunology. 2019, 10:548.
