Sialic acid is widely distributed in animal tissues and has important biological functions. To further explore the recognition and function of sialic acid residues, CD BioGlyco has established a sialylated glycan microarray to study sialic acid recognition, to help customers rapidly screen glycan-binding proteins and viruses interacting with a variety of modified sialic acids.
Protein-glycan interactions play essential roles in signal transduction, cell adhesion as well as host-pathogen interactions, and are mediated through specific glycan recognition by glycan-binding proteins. Sialic acids are targets for recognition by glycan-binding proteins, they typically occur at the non-reducing end of glycans and are distinctly diverse among monosaccharides in that many different modified sialic acids have been recognized. The sialylation of cell surface carbohydrate conjugates is highly regulated by sialyltransferases and/or sialidases, and the most commonly studied sialic acids are Neu5Gc, Neu5Ac and their 9-O-acetylated derivatives.
In recent years, researchers have successfully synthesized sialic acid glycosides containing both natural and non-natural sialic acid residues using a variety of promiscuous sialoside biosynthetic enzymes, making it possible to study sialosides containing a wider range of sialic acids. In addition, the development of chemoenzymatic methods for the synthesis of modified sialic acids and the advancement of glycan microarrays technology have improved the ability of researchers to identify and analyze glycan receptors.
Fig.1 The design and preparation of a sialylated glycan microarray. (Song, 2011)
CD BioGlyco provides customers with microarray service for a variety of sialic acids for rapid screening of binding proteins and viruses interacting with various sialic acids. The service we provide include but are not limited to:
CD BioGlyco offers new glycomics technologies for the analysis of glycan function and recognition, enabling research teams to analyze a wide range of glycans. We provide highly skilled professional services to our clients utilizing cutting-edge technologies. If you are interested in our services, please contact us for further consultation.