Nucleosides and Nucleotides
Nucleosides and nucleotides are biologically ubiquitous substances involved in almost all biochemical processes. CD BioGlyco is a leading supplier of nucleosides and nucleotides. Not only do we provide many high-quality sugar nucleotide products, but we also provide natural and modified nucleoside analogs such as phosphoramidites. These phosphoramidites can be used to synthesize oligonucleotides. Moreover, we also provide the Custom Sugar-Nucleotides Synthesis for clients to produce the custom nucleosides and nucleotides according to their requirements.
High-quality Nucleoside Products and Nucleotide Products at CD BioGlyco
CD BioGlyco offers a comprehensive range of nucleoside and nucleotide products, facilitating various biochemical and molecular biology research endeavors. These products are meticulously manufactured to meet high-quality standards and are tailored to meet the diverse needs of researchers in academia, pharmaceuticals, and biotechnology.
You can click on the product you are interested in to learn more about it or click on our "Nucleotides" button above to enter the section and browse through all of our products to find the one you are interested in. We provide more than 200 nucleotide products, aiming to match your research needs!
- Nucleotide triphosphates solutions
These include high-concentration solutions of adenosine 5'-triphosphate (ATP), guanosine 5'-triphosphate (GTP), cytidine-5'-triphosphate (CTP), and uridine 5'-triphosphate (UTP), used in DNA and RNA synthesis, and other biochemical experiments.
| Cat. No. | Product Name |
| X22-09-ZQ071 | Adenosine 5'-triphosphate (ATP) sodium salt solution, 100 mM |
| X22-09-ZQ072 | Guanosine 5'-triphosphate (GTP) sodium salt solution, 100 mM |
| X22-09-ZQ073 | Cytidine-5'-triphosphate (CTP) sodium salt solution, 100 mM |
| X22-09-ZQ074 | Uridine 5'-triphosphate (UTP) sodium salt solution, 100 mM |
- Deoxyribonucleotide triphosphate solutions
These include solutions of deoxyadenosine triphosphate (dATP), deoxyguanosine triphosphate (dGTP), deoxycytidine triphosphate (dCTP), and deoxyuridine triphosphate (dUTP), used in DNA synthesis and PCR experiments.
| Cat. No. | Product Name |
| X22-09-ZQ092 | Deoxyuridine triphosphate (dUTP) sodium salt solution, 100 mM |
| X22-09-ZQ093 | Deoxythymidine triphosphate (dTTP) sodium salt solution, 100 mM |
| X22-09-ZQ094 | Deoxycytidine triphosphate (dCTP) sodium salt solution, 100 mM |
| X22-09-ZQ095 | Deoxyguanosine triphosphate (dGTP) sodium salt solution, 100 mM |
| X22-09-ZQ096 | Deoxyadenosine triphosphate (dATP) sodium salt solution, 100 mM |
- Nucleotide mix solutions
These mixed solutions provide a balanced combination of nucleotides for polymerase chain reaction (PCR) and DNA synthesis applications.
| Cat. No. | Product Name |
| X22-09-ZQ087 | dNTP mix solution, 2.5 mM |
| X22-09-ZQ090 | dNTP/dUTP mix solution |
- Nucleotide monophosphates
These include adenosine 5'-monophosphate (AMP), cytidine 5'-monophosphate (CMP), and guanosine 5'-monophosphate (GMP), commonly used in enzymatic reactions, signaling pathways, and biochemical experiments.
| Cat. No. | Product Name |
| X23-05-YM268 | Adenosine 5'-monophosphate disodium salt |
| X23-06-YW238 | 2'-Deoxyadenosine-5'-monophosphate, Free acid |
| X23-06-YW239 | 2'-Deoxycytidine-5'-monophosphate, Free acid |
| X23-06-YW240 | 2'-Deoxyguanosine-5'-monophosphate, Free acid |
| X23-06-YW241 | 2'-Deoxythymine-5'-monophosphate, Free acid |
| X23-06-YW242 | 2'-Deoxyuridine-5'-monophosphate, Free acid |
| X23-06-YW243 | 2'-Deoxyinosine-5'-monophosphate, Free acid |
- 2'-O-methylated nucleotide triphosphate solutions
These solutions are commonly used in RNA research, RNA sequencing, and RNA polymerase reactions.
| Cat. No. | Product Name |
| X22-09-ZQ101 | (2'OMe-5'P-A)pG |
| X22-09-ZQ102 | (2'OMe-5'P-A)pU |
| X22-09-ZQ103 | (2'OMe-5'P-G)pG |
- Nucleotide phosphoramidites and linkers
These are used in solid-phase synthesis for nucleic acid synthesis, enabling the preparation of oligonucleotides and nucleotide analogs.
| Cat. No. | Product Name |
| X23-06-YW215 | Amino-modifier-C6-DT CEP |
| X23-06-YW216 | Amino-modifier-C6-DC CEP |
| X23-06-YW223 | Spacer-C6 phosphoramidite |
| X23-06-YW224 | Spacer-C12 phosphoramidite |
| X23-06-YW225 | 5'-Amino-modifier C6-TFA-phosphoramidite |
| X23-06-YW226 | 5'-Amino-modifier C12-TFA-phosphoramidite |
| X23-06-YW227 | Monomethoxytrityl-C6-hexylamine-linker phosphoramidite |
| X23-06-YW228 | Monomethoxytrityl-C12-hexylamine-linker phosphoramidite |
- Modified nucleotides and derivatives
These include various modified nucleotides used in specific biochemical research and laboratory applications.
| Cat. No. | Product Name |
| X22-09-ZQ108 | Morpholino A subunit |
| X22-09-ZQ109 | Morpholino C subunit |
| X22-09-ZQ110 | Morpholino T subunit |
| X22-09-ZQ111 | Morpholino G subunit |
| X22-09-ZQ579 | m7Gpp |
- Nucleotide sugars
These such as UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine, are used in glycosylation reactions and studies of sugar metabolism.
| Cat. No. | Product Name |
| X22-11-ZQ495 | UDP-α-D-glucose ammonium salt |
| X22-11-ZQ496 | UDP-β-L-glucose ammonium salt |
| X22-11-ZQ497 | TDP-α-D-glucose ammonium salt |
| X22-11-ZQ498 | TDP-α-D-fucose ammonium salt |
| X22-11-ZQ499 | TDP-β-L-rhamnose ammonium salt |
| X22-11-ZQ500 | GDP-β-L-glucose ammonium salt |
- Other nucleotide-related compounds
Various derivatives and modifications are used in nucleic acid chemistry and synthesis, including methylated and modified nucleotides.
At CD BioGlyco, we prioritize precision and purity in every nucleoside offering, ensuring researchers and developers access the finest materials for their projects. From nucleoside analogs crucial for cancer chemotherapy to nucleoside derivatives essential for nucleic acid synthesis and modification, our range encapsulates the forefront of biochemical innovation.
Feel free to explore further by clicking on the specific product you're interested in, or navigate to our "Nucleosides" section using the button above to browse through our extensive collection of over 300 nucleotide products.
- Precursors of chemotherapeutic agents
Precursors of chemotherapeutic agents are vital components in the synthesis of medications aimed at combating cancer. They serve as foundational elements in the creation of drugs that target specific mechanisms within cancer cells, offering hope and potential in cancer treatment strategies.
| Cat. No. | Product Name |
| X22-07-ZQ364 | Capecitabine |
| X22-07-ZQ368 | 2-Thio-6-azauridine |
| X22-07-ZQ369 | 2-Cl-IB-MECA |
| X22-07-ZQ379 | Zebularine |
- Nucleoside derivatives
Nucleoside derivatives play pivotal roles in the exploration of nucleic acid structures and functions. They serve as essential tools in understanding DNA and RNA biology, offering researchers insights into molecular mechanisms and potential therapeutic targets.
| Cat. No. | Product Name |
| X22-07-ZQ367 | Nicotinamide ribose |
| X22-07-ZQ370 | β-Pseudouridine |
| X22-07-ZQ371 | 3-Deazaadenosine |
| X22-07-ZQ372 | 5-Azidouridine |
| X22-07-ZQ375 | 5-Bromouridine |
| X22-07-ZQ376 | 5-Iodouridine |
| X22-07-ZQ377 | 5-Chlorouridine |
| X22-07-ZQ378 | 5-Azido-2'-deoxyuridine |
| X22-07-ZQ380 | 2,6-Dichloro-9β-(2',3',5'-tri-O-acetyl)-D-ribofuranosylpurine |
| X22-07-ZQ381 | 2-Chloroadenosine |
| X22-07-ZQ382 | 2-Chloro-6-methoxypurine riboside |
| X22-07-ZQ383 | UDP-xylose |
- Nucleic acid synthesis reagents
Nucleic acid synthesis reagents are indispensable in the laboratory for the construction and modification of DNA and RNA molecules. These reagents enable scientists to manipulate nucleic acids with precision, facilitating research in genetics, molecular biology, and therapeutic development.
| Cat. No. | Product Name |
| X22-09-ZQ064 | DMT-dA(PAc) phosphoramidite |
| X22-09-ZQ065 | DMT-dG(IPAc) phosphoramidite |
| X22-09-ZQ066 | DMT-dU-CE phosphoramidite |
| X22-09-ZQ575 | Bis(2-cyanoethyl) diisopropylphosphoramidite |
| X22-09-ZQ582 | 2'-O-Methyluridine |
| X22-09-ZQ583 | 2'-O-Methylcytidine |
- Transcription and translation-related substances
Substances related to transcription and translation are crucial for unraveling the intricacies of gene expression. They play fundamental roles in deciphering how genetic information is transcribed into RNA and translated into proteins, offering insights into cellular processes and potential therapeutic interventions.
| Cat. No. | Product Name |
| X23-03-YW133 | GpppG |
| X23-03-YW134 | M7-GpppG |
| X23-03-YW135 | ARCA |
| X23-03-YW136 | Cap 0 |
| X23-03-YW137 | GAG |
| X23-03-YW138 | 3-OME-GAG |
- Nucleoside compounds
Nucleoside compounds form the backbone of biochemical research and pharmaceutical development. They serve as building blocks for nucleic acids and are instrumental in studying molecular interactions, cellular signaling pathways, and disease mechanisms, paving the way for innovative therapeutic approaches and drug discovery.
| Cat. No. | Product Name |
| X23-06-YW001 | 2'-Deoxyadenosine monohydrate |
| X23-06-YW002 | 2'-Deoxycytidine |
| X23-06-YW003 | 2'-Deoxyguanosine monohydrate |
| X23-06-YW004 | 2'-Deoxythymine |
| X23-06-YW005 | 2'-Deoxyuridine |
| X23-06-YW006 | 2'-Deoxyinosine |
| X23-06-YW008 | 2'-Deoxyadenosine |
| X23-06-YW009 | 2'-Deoxyguanosine |
| X23-04-XQ829 | Adenosine |
| X23-06-YW015 | 5-Methylcytidine |
| X23-06-YW016 | 5-Methyluridine |
| X23-06-YW017 | 5-Methyl-2'-O-methylcytidine |
| X23-06-YW018 | 5-Methyl-2'-O-methyluridine |
Publication
DOI: https://www.mdpi.com/2075-1729/8/4/57
Technology: Formose reaction, Chemical catalysis, Photochemical processes, Bioinformatics
Published: 2018
Results: The study delves into the origins of RNA nucleosides and nucleotides, crucial components in the evolution of life, by examining prebiotic chemical reactions that could have occurred on the early Earth. The research highlights various plausible synthetic pathways for forming ribose sugars, nucleobases, and their subsequent assembly into nucleosides and nucleotides. Despite advances, the study acknowledges ongoing challenges in achieving efficient and selective synthesis under prebiotic conditions. The findings contribute to our understanding of how life's molecular building blocks might have spontaneously formed before the advent of biological processes.
Fig.1 Possible routes for the synthesis of nucleotides. (Biscans, 2018)
Applications
- Nucleoside analogs are used as antiviral drugs to treat infections such as HIV, hepatitis B, and hepatitis C by inhibiting viral replication.
- Nucleotides are essential components in PCR and DNA sequencing technologies, facilitating the amplification and analysis of genetic material.
- Nucleotides are used in assays to detect genetic mutations and polymorphisms, aiding in the diagnosis of hereditary diseases.
- Nucleotides and their derivatives are used to promote plant growth and enhance crop yields.
- Nucleotides are used to develop infant formulas and sports nutrition products to support cellular growth and immune function.
Advantages
- Nucleoside analogs can specifically target viral or cancerous cells, minimizing damage to healthy cells.
- Nucleosides and nucleotides are used across various fields, including medicine, biotechnology, and agriculture.
- Nucleosides and nucleotides can be easily synthesized and modified to enhance their properties, such as increasing stability or bioavailability.
- As fundamental components of DNA and RNA, nucleosides and nucleotides are crucial for all cellular processes, including replication, transcription, and translation.
Frequently Asked Questions (FAQs)
Can CD BioGlyco provide customized nucleosides and nucleotides for specific research needs?
Yes, CD BioGlyco offers customized solutions to meet specific research requirements:
- Tailored synthesis: Custom synthesis services to produce nucleosides and nucleotides with specific modifications or labels.
- Consultation services: Expert consultation to help design and develop customized nucleotides for unique applications.
- Flexible quantities: Offering products in various quantities to suit both small-scale research and large-scale industrial needs.
What support and resources does CD BioGlyco offer to researchers using its nucleosides and nucleotides products?
CD BioGlyco provides extensive support and resources, including technical support, comprehensive documentation, educational resources, and customer service.
CD BioGlyco offers a comprehensive range of high-quality nucleosides and nucleotides, designed to meet the diverse needs of researchers and professionals in the development of biotechnology, medicine, and diagnostics. Please feel free to contact us to get the quote according to your needs!
Reference
- Biscans, A. Exploring the emergence of RNA nucleosides and nucleotides on the early Earth. Life. 2018, 8(4): 57.
