Galactose is converted into galactosamine by replacing the 2-hydroxyl group with an amino group. D-galactosamine and D-glucosamine are C4-heterotropic isomers. In nature, it is a component of glycoproteins and proteoglycans that form the support material of animal cells and tissues and is mostly bound in the form of N-acetylgalactosamine. Galactosamine is a component of hyaluronic acid, a powerful water-retaining agent that acts as a lubricant in synovial fluid, connective tissue, and eyeball vitreous fluids. D-galactosamine is a disrupter of uracil nucleoside in hepatocytes, leading to uracil nucleoside depletion and liver transcriptional dysfunction. It results in the inhibition of biosynthesis of nucleic acids, glycoproteins, glycolipids, etc., thus limiting the production and recruitment of organelles and enzymes.
Fig.1 Mechanism of hepatotoxicity induced by D-galactosamine. (Maes, et al., 2016)
Galactosamine is an important component of living cells and a typical model hepatotoxin used to study the mechanisms of liver injury. CD BioGlyco has mastered the technology of galactosamine metabolism analysis and has professional analysts to provide clients with efficient and economical galactosamine metabolism analysis services.
Fig.2 Sample pretreatment process. (CD BioGlyco)
CD BioGlyco has a wealth of practical experience in Monosaccharide Metabolism Analysis, ensuring that clients obtain accurate and reproducible analysis results in a fast and cost-effective manner. If you are looking for a carbohydrate metabolism analysis solution, please stop your search and contact us immediately.