Galacturonic acid is a monomer of pectin, which is found in many agricultural wastes, such as beet pulp and citrus peel, and is often used as animal feed or gel. In the human body, galacturonic acid is both a nutrient and a signaling molecule that can guide the delicate microbiota-pathogen relationship in the gastrointestinal tract. It has been shown to regulate the toxicity and intestinal localization of pathogens such as enterohemorrhagic Escherichia coli and Citrobacter rodentium.
Fig.1 Chemical structures of different pectin. (Richard & Hilditch, 2009)
Many prokaryotes and eukaryotes catabolize galacturonic acid. In Escherichia coli, galacturonic acid is converted to pyruvate and D-aldehyde-3-phosphate by the isomerase pathway. In Agrobacterium tumefaciens, it is converted to 2-keto-glutarate through the oxidative pathway. Galacturonic acid is also metabolized through the eukaryotic pathway, and yeast and molds grow on it as the sole carbon source.
Galacturonic acid is catabolized into useful products in many microorganisms and even plants. It is of great significance to study galacturonic acid metabolism. CD BioGlyco has advanced equipment and professional personnel, and we will provide clients with cost-effective galacturonic acid metabolism analysis services.
Fig.2 Flowchart of galacturonic acid analysis. (CD BioGlyco)
CD BioGlyco also provides other Monosaccharide Metabolism Analysis Services, as well as Disaccharide, Oligosaccharide, and Polysaccharide Metabolism Analysis Services. Please feel free to contact us when you need timely customized Solutions. We look forward to being with you.