CD BioGlyco has developed a complete lipidomics analysis solution for clients. We provide fast, efficient, and accurate ganglioside analysis services by mass spectrometry (MS). Welcome global clients to establish cooperation with us!
Gangliosides are composed of acidic glycosphingolipids with one or more N-acetylneuraminic acid (NANA) residues attached to the sugar chain. In 1942, German scientist Ernst Klenk first named gangliosides for lipids isolated from ganglion cells in the brain. Gangliosides are the structural components of cell membranes, with their two hydrocarbon chains embedded in the plasma membrane, while oligosaccharides are located on the extracellular surface. They provide recognition points for extracellular substances or surface molecules of adjacent cells and play an important role in cell recognition, adhesion, and signaling transmission.
Gangliosides are a complex class of lipids that are synthesized primarily in the endoplasmic reticulum (ER), and then further modified in the Golgi by the sequential addition of additional carbohydrates. Except monosialogangliosides 4 (GM4) derived from galactosylceramide (GalCer), most gangliosides are synthesized from lactosylceramide (LacCer). The gangliosides derived from LacCer are divided into asialo-series gangliosides, a-series gangliosides, b-series gangliosides, and c-series gangliosides according to the number of sialic acid residues linked to the internal galactose (Gal) residues.
Fig.1 Structures and biosynthetic pathways of gangliosides. (Robert, et al., 2011)
Gangliosides are found in most mammalian tissues and are most abundant in the nervous system. Their unique physical properties make them important parts of the cell membrane, involved in cell recognition and cell communication. Studies have shown that gangliosides are essential for neuronal function and brain development. They provide neuroprotection by promoting neurodevelopment in newborns and are involved in memory and learning in the brain. Furthermore, gangliosides have been implicated in the pathology of many diseases, such as Guillain-Barré syndrome, which is caused by an autoimmune response to cell surface gangliosides. Alzheimer's disease is also thought to be initiated by the aggregation of amyloid-β peptides caused by gangliosides.
At CD BioGlyco, we have developed a high-sensitivity, reproducible, high-resolution, and high-accuracy solution for sphingolipid analysis. We provide GM, disialogangliosides (GD), trisialogangliosides (GT), and tetrasialogangliosides (GQ) analysis in various sample types by Q Exactive Orbitrap-MS. Gangliosides we analyze include but are not limited to GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, and GQ1.
|GM||GM1||Q Exactive Orbitrap-MS||
|GM2||Q Exactive Orbitrap-MS|
|GM3||Q Exactive Orbitrap-MS|
|GM4||Q Exactive Orbitrap-MS|
|GD||GD1||Q Exactive Orbitrap-MS||
|GD2||Q Exactive Orbitrap-MS|
|GD3||Q Exactive Orbitrap-MS|
|GT||GT1||Q Exactive Orbitrap-MS||
|GT2||Q Exactive Orbitrap-MS|
|GT3||Q Exactive Orbitrap-MS|
|GQ||GQ1||Q Exactive Orbitrap-MS||
In addition, we also provide diverse ganglioside products for global clients, including but not limited to:
|Cat. No.||Product Name||Cat. No.||Product Name|
|XGB754||Asialoganglioside GM1 from bovine brain||XGB990||Ganglioside GD3, Disialo, Diammonium Salt, Bovine Buttermilk|
|XGB755||Asialoganglioside-GM2 from bovine brain||XGB991||Ganglioside GD1a, Disialo, Diammonium Salt, Bovine Brain|
|XGB756||Disialoganglioside GD2 from bovine brain||XGB992||Ganglioside GD1b, Disialo, Human Brain|
|XGB757||Disialoganglioside GD1a from bovine brain||XGB993||Ganglioside GM1, Ammonium Salt, Bovine Brain|
|XGB758||Disialoganglioside GD1b from bovine brain||XGB994||Ganglioside GM1, Asialo, Human Brain|
|XGB759||Lysoganglioside GM1 from bovine brain||XGB995||Ganglioside GM3, Monosialo, Ammonium Salt, Bovine Milk|
|XGB760||Monosialoganglioside GM3 from canine blood||XGB996||Ganglioside GM4, Monosialo, Human Brain|
|XGB761||Monosialoganglioside GM1 from bovine brain, ≥95%||XGB997||Ganglioside GQ1b, Tetrasialo, Tetraammonium Salt, Bovine Brain|
|XGB762||Monosialoganglioside GM1 from bovine brain, BioXtra, γ-irradiated, ≥95% (TLC)||XGB998||Ganglioside GT1b, Trisialo, Triammonium Salt, Bovine Brain|
|XGB763||Monosialoganglioside GM2 from bovine brain||XGB999||Lysoganglioside-GM1 from bovine brain|
|XGB764||Trisialoganglioside GT1b from bovine brain||XGB1004||Trisialoganglioside-GT1b from bovine brain|
|XGB989||Ganglioside GD2, Disialo, Human Brain|
CD BioGlyco has extensive experience in lipidomics and has developed various lipid analysis methods. We are willing to share our knowledge and experience in this field. If you are interested in our services and products, please contact us for more details without any hesitation.