Accurate Diatrizoate Meglumine Analysis, Reliable Results: Your Trusted Research Partners

Diatrizoate meglumine is the meglumine salt form of pantethine and is usually kept in airtight containers. It has an important role in medicine, for example, it is used as a water-soluble contrast agent. At CD BioGlyco, we provide high-quality diatrizoate meglumine analysis services to our clients based on our extensive experience in the field of Pharmaceutical and Biological Analysis.

High-quality Diatrizoate Meglumine Analysis Service at CD BioGlyco

• Identification of diatrizoate meglumine
  • Heating method: The sample to be tested is placed in a crucible and heated, if purple vapor appears then the sample is diatrizoate meglumine.
  • Thin layer chromatography (TLC): The sample to be tested and the diatrizoate meglumine standard are dissolved under the same conditions and expanded on a TLC plate, which is illuminated with an ultraviolet (UV) lamp to compare the positions of the spots on the chromatographic plate. If the positions are identical, the sample to be tested is diatrizoate meglumine.
• Optical rotation analysis
  A sample of diatrizoate meglumine is dissolved in water, and we test its optical rotation using a spinometer.
• Loss of drying analysis
  Diatrizoate meglumine is dried by heating to above 100°C. Theoretically, the loss of weight does not exceed 1.0% of the weight before drying.
• Scorch residue analysis
  Diatrizoate meglumine is cauterized and the residue is weighed. Theoretically, the weight of the residue does not exceed 0.1% of the weight before cauterization.
• pH analysis
  Diatrizoate meglumine is dissolved in water, followed by a pH meter to test its pH.
• Free Iodine analysis
  First, we dissolve the diatrizoate meglumine sample using a sodium hydroxide solution. Next, dilute acetic acid is added to adjust the acidity of the solution. Finally, potassium iodide solid and starch indicator solution are added to it. If the solution shows color, it means that the sample contains free iodine.
• Free amine analysis
  We analyze diatrizoate meglumine for the presence of free amines using ultraviolet-visible (UV-Vis) spectrophotometry. Diatrizoate meglumine is dissolved in water under light-protected conditions. The presence of free amines is then analyzed by measuring its absorbance at 470 nm using a UV-Vis spectrophotometer.
• Meglumine content analysis
  The concentration of meglumine (C₇H₁₇NO₅) contained in the sample is obtained by determining the rotativity of diatrizoate meglumine at room temperature and dividing the result by 24.9.

In addition, diatrizoate meglumine is also commonly used in the medical field in the form of diatrizoate meglumine injection, which is a sterilized aqueous solution of pantothenic acid with equal molecules of glucosamine in a clear colorless to pale yellow liquid. It is worth mentioning that diatrizoate meglumine injection is analyzed in the same manner as diatrizoate meglumine described above. Therefore, at CD BioGlyco, we also analyze it in the same comprehensive manner as described above.

Fig,1 Diatrizoate meglumine analysis services. (CD BioGlyco)

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• We combine biological expertise with pharmaceutical analysis techniques to help our clients develop competitive products.

CD BioGlyco offers custom pharmaceutical analysis services to meet our client's project development goals. For more information and a detailed quote, please feel free to contact us.

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