Glycopeptide-based Glycomedicine Development

CD BioGlyco has professional glycomedicine development teams with multiple world-leading technologies to help customers comprehensively promote the development of glycopeptide-based glycomedicine.

Glycopeptides and Glycosylation

Glycopeptides are peptides that contain carbohydrate moieties (glycans) covalently attached to the side chains of the amino acid residues that constitute the peptide. Over the past few decades, it has been recognized that glycans on the cell surface (attached to membrane proteins or lipids) and those bound to proteins (glycoproteins) play a critical role in biology. For example, these constructs have been shown to play important roles in fertilization, the immune system, brain development, the endocrine system, and inflammation. The synthesis of glycopeptides provides biological probes for researchers to elucidate glycan function in nature and products that have useful therapeutic and biotechnological applications.

Glycosylation is a post- or co-translational modification of proteins and it has extensive biological significance. In general, protein function is influenced by the covalent attachment of an oligosaccharide to its surface. Altered protein glycosylation patterns often modify intercellular recognition processes, through modulation of protein-protein or protein-carbohydrate interactions. Moreover, glycosylation increases peptide hydrophilicity, resulting in increased aqueous solubility and altered clearance properties compared with the naked peptide. Glycosylation may also play a role in protein folding, as well as functioning as an inducer of protein secondary structure. As such, the fields of glycobiology and carbohydrate chemistry offer a myriad of research opportunities in the biological arena.

Fig 1. Examples of biologically active synthetic glycopeptide constructs.Fig.1 Examples of biologically active synthetic glycopeptide constructs. (Boltje, et al., 2009)

Glycopeptide-based Glycomedicine Development Services

Glycopeptide synthesis represents an essential tool for the study of the structure and function of glycopeptide. CD BioGlyco has developed a highly specialized carbohydrate-based glycomedicine development platform and various systematic solutions for the synthesis of glycopeptide-based glycomedicine. Our services include but are not limited to:

  • Synthesis of N- glycopeptide.

Glycosylation through the side-chain amide of asparagine. This biosynthetic modification of proteins occurs co-translationally in the endoplasmic reticulum through the action of oligosaccharyltransferase.

  • Synthesis of O- glycopeptide.

Glycosylation through the side chain hydroxyl of serine, threonine, or tyrosine.

  • Synthesis of C- mannosylation.

C-mannosylation is unique in that an α-mannose is directly bound to the indole C2 carbon atom of a tryptophan residue through a C–C bond.

Advantages of Us

  • Advanced modification technology platforms and professional research teams.
  • High purity and reliable quality.
  • Guaranteed quantity with a competitive price.

CD BioGlyco is committed to offering high-quality glycopeptide-based glycomedicine development services within the agreed timeline. We aim to share our knowledge and passion in the glycobiology and glycochemistry field.

If you are interested in our services, please contact us to obtain more information.

Reference:

  1. Boltje, T.J.; et al. Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research. Nature Chemistry. 2009, 1(8): 611-622.
This service is for Research Use Only, not intended for any clinical use.

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