Custom Carbohydrate Synthesis

Overview

Advanced chemical and enzymatic methods have enabled the synthesis of various saccharides. CD BioGlyco has developed highly integrated approaches that can combine chemical and enzymatic methods to quickly compose saccharide-related products. We can complete small (mg) and large (g) quantities of saccharides and transfer the technology to a bulk manufacturing plant. All our final products will be thoroughly analyzed by our advanced technologies such as mass spectrometry and high field NMR to ensure quality.

Our team of professionals, most with a Ph.D. degree, is highly skilled in the areas of carbohydrate, nucleosidation, glycosylation, high purity complex products, and synthetic route development. We are proficient in the design and customization of complex multi-step reaction schemes and provide customers with customized overall solutions in the fields of biopharmaceuticals, therapy, and diagnosis to develop saccharides and saccharide-related molecules.

Key Technologies

Enzymatic synthesis; Chemical synthesis

Precision-Crafted Sugars, Scientifically Defined

We leverage a comprehensive array of established and innovative techniques to ensure the successful and efficient construction of even the most challenging carbohydrate structures. Our core technologies include both enzymatic and chemical synthesis approaches. Enzymatic synthesis offers unparalleled stereo- and regioselectivity, mimicking natural biosynthetic pathways to create complex glycans with high fidelity.

Custom Monosaccharide Synthesis

We offer custom synthesis of monosaccharides and their derivatives through the multistep chemical or enzymatic synthesis method according to the scientific requirements of our clients.

Custom Disaccharide Synthesis

The first-class experimental platform and rich synthesis experience ensure that we provide customers with high-quality and high-purity customized disaccharide synthesis services.

Custom Oligosaccharides Synthesis

CD BioGlyco provides chemical and enzymatic methods and their combination with multiple disciplines to help customers in-depth study the structure and function of oligosaccharides.

Custom Complex N-linked Oligosaccharides Synthesis

CD BioGlyco has accumulated extensive experience in the synthesis of complex N-linked oligosaccharides by efficient and concise methods, to help customers in terms of glycobiology.

Custom Polysaccharides Synthesis

We have many years of successful experience in the synthesis and modification of polysaccharides, and we can customize a variety of polysaccharides with different labels according to the research needs of customers.

Custom Sugar-Nucleotides Synthesis

CD BioGlyco combines chemical and enzymatic synthesis methods to synthesize sugar nucleotides, making them no longer difficult to synthesize.

Custom Carbohydrate Antigens Synthesis

We not only provide advanced carbohydrate antigen synthesis technology platforms but also many first-class antigen verification methods such as NMR and glycan microarray analysis.

Workflow

Our workflow. (CD BioGlyco)

Publication Data

DOI.: 10.3390/catal10101142

Technology: Solvent-free reaction

Journal: Catalysts

IF: 3.8

Published: 2020

Results: This comprehensive review explores solvent-free methodologies in carbohydrate synthetic chemistry, emphasizing the pivotal role of catalysis in enhancing reactivity and selectivity. The authors analyze a wide range of solvent-free techniques, including mechanochemical ball milling, melt reactions, and catalytic solid-state processes, for key transformations such as protecting group manipulations (acylations, acetalations, benzylations), glycosylations, glycoconjugations, and biomass depolymerization. Crucially, the review highlights how catalysts (e.g., Lewis acids like In(OTf)₃, Yb(OTf)₃; solid acids; enzymes; organotin reagents) enable precise control over regioselectivity and stereoselectivity in these solvent-free environments, often offering advantages like simplified procedures, improved yields, or unique selectivity profiles compared to traditional solvent-based methods. The work underscores the growing potential of solvent-free, catalytically driven approaches as sustainable and efficient strategies for constructing complex carbohydrates and valorizing biomass-derived sugars.

Applications

Generating fluorescently or radio-labeled glycans to track metabolism, localization, and interactions within cells and organisms.
Creating affinity tags (e.g., biotinylated glycans) for isolating and characterizing glycan-binding proteins.
Developing activity-based probes (ABPs) for studying enzyme activity in complex biological samples.

Advantages of Us

Expertise in both enzymatic synthesis (for natural fidelity) and advanced chemical synthesis (for diverse scaffolds) provides unmatched flexibility.
Enzymatic synthesis utilizing glycosyltransferases/glycosidases ensures unparalleled stereo- and regioselectivity, enabling complex structures.
The integrated approach combining synthesis and advanced analytics guarantees stringent quality control, optimizing yield, purity, and structural integrity.

Frequently Asked Questions

Associated Services

100 Glycan Microarray	Genetic Cell Surface Glycoengineering Service

The synthesis laboratory at CD BioGlyco uses the most advanced synthesis technology to provide customers with the customized synthesis of oligosaccharides, polysaccharides, sugar-nucleotides, and carbohydrate antigens. Our mission is to help academic laboratories and industries explore the biological and pharmaceutical effects of saccharides. If you have any further queries, please contact us directly for more detailed information.

Reference

Traboni, S.; et al. Solvent-free approaches in carbohydrate synthetic chemistry: role of catalysis in reactivity and selectivity. Catalysts. 2020, 10(10): 1142. (Open Access)

This service is for Research Use Only, not intended for any clinical use.

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