What Is Mannuronic Acid?

D-mannuronic acid and L-guluronic acid are components of alginic acid, a polysaccharide mainly found in brown algae. Studies have shown that D-mannuronic acid has shown positive pharmacological activity in a variety of experimental models, including nephrotic syndrome and acute glomerulonephritis. It has a high safety as a disease therapy and a good prospect of becoming a non-steroidal anti-inflammatory drug.

Fig.1 Chemical structure of D-mannuronic acid. (Wikipedia)

Mannuronic Acid Analysis Service at CD BioGlyco

Based on the excellent pharmacological activity and safety of mannuronic acid in vivo, it is of great significance to study its metabolic process. After years of technical accumulation, CD BioGlyco has a mature system and optimized process for mannuronic acid metabolism analysis.

• Detection methods
  
  • Gas chromatography-mass spectrum (GC-MS): GC has the advantages of high sensitivity and good reproducibility. It is suitable for the analysis and detection of volatile substances. In the analysis of mannuronic acid, we will derive the monosaccharide by chemical methods. CD BioGlyco provides free derivatization services.
  • High-performance liquid chromatography (HPLC): The qualitative and quantitative determination of mannuronic acid is mostly done by HPLC. The sample components are separated according to the charge and polarity of the molecule, and pre-column derivatization is not necessary.
  • High-performance anion exchange chromatography (HPAEC): HPAEC achieves high-resolution analysis without derivatization, which separates each component according to the different pKa. This is the approach most recommended by our engineers.
  • Nuclear magnetic resonance (NMR): The detection method based on the NMR system has been maturely applied to carbohydrate analysis. At CD BioGlyco, it is possible to identify more than two dozen components simultaneously. It is fast, sensitive, and efficient, but not so economical.

Fig.2 Different methods of mannuronic acid metabolism analysis. (CD BioGlyco)

• Sample pretreatment: According to the test method you choose, we provide the appropriate sample pretreatment services, including chemical derivatization. Both solid and liquid samples are acceptable. Please ensure that your samples are sufficient.
• The test report: We will generate a detailed test report, including experimental steps, test parameters and pictures, raw data, and the final summary.

Applications

• Qualitative and quantitative analysis of mannuronic acid
• Determination of mannuronic acid in complex metabolites
• Study on metabolic pathway of mannuronic acid

Highlights

• One-on-one solution and free consultation
• Senior research and development team
• Leading detection speed in the industry
• 24-hour detection and analysis service

With extensive experience, Carbohydrate Metabolism Analysis services at CD BioGlyco are well-received by clients around the world. If you are looking for the best mannuronic acid metabolism analysis, we are the one for you. Please contact us immediately for more information.