Traditional Glycan Display Array

Traditional Glycan Display Array

At CD BioGlyco, we provide a cutting-edge service for traditional glycan display arrays. This specialized offering is designed to propel glycobiology research, biomarker discovery, and glycan-protein interaction studies to new heights. Our service encompasses three key components including oligosaccharide library construction, library immobilization, and glycan microarray assay, each executed with precision and expertise.

Oligosaccharide Library Construction Service at CD BioGlyco

CD BioGlyco offers custom synthesis services for glycan libraries tailored for microarray chip applications, typically focusing on oligosaccharides. Our services encompass the design and synthesis of specialized glycan libraries to meet the specific requirements of microarray chip experiments.

This service includes the preparation of defined oligosaccharide structures, tailored to the client's needs, ensuring high quality and reproducibility. Our expertise in glycan synthesis enables the generation of custom glycan libraries suitable for diverse applications, such as glycan microarray assays, facilitating advanced studies in glycobiology, biomarker discovery, and glycan-protein interactions.

Cell Surface Glycoengineering Service

Besides these oligosaccharide library construction services, CD BioGlyco also utilizes technologies such as metabolic and genetic engineering to enable controlled editing of cell surface glycan display for cell-based glycan display array.

Oligosaccharide Library Immobilization Service at CD BioGlyco

Our oligosaccharide library immobilization service offers a comprehensive solution for stable and reproducible glycan immobilization. Our expert team excels in coupling synthesized oligosaccharides to both N-hydroxysuccinimide-activated glass slides and epoxide-activated glass slides, ensuring robust attachment and preservation of glycan integrity. Moreover, we also provide expertise in depositing glycolipids and lipid-derivatized glycans onto nitrocellulose-coated slides, expanding the versatility of interactions.

Fig.1 Glycan immobilization and epitope recognition on a microarray. (Kiessling & Christopher, 2002)Fig.1 Glycan immobilization and epitope recognition on a microarray. (Kiessling & Christopher, 2002)

Glycan Microarray Assay at CD BioGlyco

CD BioGlyco's glycan microarray assay services offer a comprehensive exploration of glycan-protein interactions. These specialized assays provide in-depth insights into diverse glycan categories, allowing researchers to unravel the complexities of microbial surface structures, human milk oligosaccharides, sialylated glycans, glycosaminoglycans, and blood group antigens. The advantages include high-throughput screening, customization options, and significant contributions to glycobiology research and biomarker discovery. Choose CD BioGlyco for a transformative journey into the intricate world of glycans and their interactions!

Fig.2 The glycan microarray story from construction to applications. (Hyun, et al.,2017)Fig.2 The glycan microarray story from construction to applications. (Hyun, et al., 2017)


Technology: Carbohydrate microarrays, Glycan–protein interactions, One-step surface modification, Fluorescent detection

Journal: Accounts of Chemical Research

IF: 18.3

Published: 2017

Results: The presence of carbohydrates in glycoconjugates, such as glycoproteins and glycosphingolipids, plays a crucial role in physiological and pathological processes, engaging in interactions with glycan-binding proteins (GBPs). Carbohydrate microarrays, pioneered in 2002, facilitate the simultaneous analysis of multiple glycan–protein interactions, providing a powerful tool for studying glycans and GBPs. This technology enables rapid assessment of binding events, determination of affinities, substrate specificity of enzymes, pathogen detection, and identification of functional glycans influencing cellular responses, offering valuable insights into pathophysiological processes and potential therapeutic applications.

Fig.3 Glycans immobilized on a microarray (top) are displayed in a multivalent manner like cell surface glycans (bottom). (Hyun, et al.,2017)Fig.3 Glycans immobilized on a microarray (top) are displayed in a multivalent manner like cell surface glycans (bottom). (Hyun, et al., 2017)


  • Explore potential drug targets and interactions by studying the binding patterns of glycans with proteins, aiding in the discovery of therapeutic agents.
  • Characterize glycan-protein interactions relevant to pathogenicity, contributing crucial data for the development of vaccines against infectious diseases.
  • Investigate the dynamics of glycan-enzyme interactions, providing insights into enzymatic processes and potential targets for enzyme modulation.


  • Utilize state-of-the-art carbohydrate microarray technology provided by CD BioGlyco, to facilitate comprehensive studies of glycan–protein interactions.
  • Benefit from a high-density array featuring a diverse range of glycans immobilized on a solid surface, allowing for the simultaneous analysis of multiple interactions.
  • Leverage the multivalent display of carbohydrates on the solid surface, enhancing interactions with proteins and enabling sensitive and rapid assessments even with low-affinity binding partners.

At CD BioGlyco, we explore the forefront of glycobiology with our glycan microarray services. Join us in advancing research and unraveling the intricacies of glycan-mediated events with precision and efficiency. Please do not hesitate to contact us for more details!


  1. Kiessling, L.L.; Christopher W.C. Hitting the sweet spot. Nature Biotechnology. 2002, 20(3): 234-235.
  2. Hyun, J.Y.; et al. The glycan microarray story from construction to applications. Accounts of chemical research. 2017, 50(4): 1069-1078.
This service is for Research Use Only, not intended for any clinical use.

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