Glycan antibodies are part of the antibody molecules that interact specifically with the structure of glycans. They are a special class of antibodies that, unlike traditional antibodies, do not recognize and bind biological macromolecules such as proteins, peptides, or nucleic acids. Through their binding to specific glycans, they recognize and distinguish different glycan structures on the cell surface and play a role in important physiological processes such as cognition, recognition and clearance of pathogens, and apoptosis. The principle of HTS of antibody glycans is to use high-throughput technology to rapidly screen a large number of glycan structures from which antibody candidates with high affinity for glycan antigens can be identified. This approach allows rapid screening of antibodies with specific glycan structures that play an important role in drug development and therapy.
Glycoconjugate antibodies are diverse and specific, and different types of antibodies recognize different glycan antigens, so efficient identification and screening of specific glycoconjugate antibodies are very important for relevant research. We provide comprehensive high-quality high-throughput antibody glycan screening services and subsequent activity test services for our clients worldwide:
Fig.1 Techniques for high-throughput glycan screening of antibodies. (CD BioGlyco, 2023)
CD BioGlyco specializes in providing the most professional high-throughput glycan screening service to help our clients conduct in-depth research in glycobiology. We have a professional team including several experienced glycochemists and biologists who provide quality customized high-throughput glycan screening for antibodies to our clients and personalized solutions. If you would like more information about our services, please feel free to contact us.