Gadobenate Dimeglumine Injection Analysis Service
We Provide Reliable Gadobenate Dimeglumine Injection Analysis for Our Clients
CD BioGlyco offers complete analytical services for Pharmaceutical studies. Gadobenate dimeglumine injection is used for magnetic resonance imaging of the liver and central nervous system. With our extensive experience in Pharmaceutical and Biological Analysis, we offer a very comprehensive gadobenate dimeglumine injection analysis service. Our analytical techniques include thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), ultraviolet-visible (UV-vis) spectroscopy, etc.
- Analytical methods at CD BioGlyco
- TLC is a versatile separation method widely used for sample identification and quantification. It is used to analyze almost any class of substances.
- HPLC is a commonly used method for drug analysis, which is characterized by good separation, rapidity, high detection sensitivity, detection automation, etc.
- UV-vis spectroscopy is a commonly used method for identification, impurity checking, and quantitative determination.
- Analyzed items at CD BioGlyco
- Clarity and color: We use UV-vis spectroscopy to measure the absorbance at 450 nm.
- Detection of related substances: The content of impurities, sodium pyruvate, and benzyl alcohol is detected by HPLC.
- Identification of gadobenate dimeglumine injection: The content of gadobenate dimeglumine is detected by TLC to identify the sample.
- Determination of content:
- Gadobenic acid: HPLC is used to determine the content in the samples using octylamine solution-acetonitrile as the mobile phase.
- N-Methylglucamine: After diluting the sample with water, we detect its content by spin chromatography.
- Other items: Trait observation, heavy metal content detection, bacterial endotoxin detection, free acid, and free gadolinium content detection, etc.
Fig.1 Process of gadobenate dimeglumine injection analysis. (CD BioGlyco)
Publication Data
Technology: HPLC
Journal: The British Journal of Radiology
IF: 1.84
Published: 2015
Results: In the present study, gadobenate dimeglumine was injected into diseased mice, and the recovery of gadobenate ion after drug administration was analyzed by HPLC to detect the protective mechanism of the organism against impaired renal function. The results showed that the gadobenate ion in plasma was less than 0.12% of the injected dose at 8 hours after injection. Urinary excretion of gadobenate ion was significantly higher than that of normal rats. The results suggest that gadobenate ion is eliminated through urinary or hepatobiliary pathways in rats with impaired renal function.
Fig.2 Residual gadolinium levels in liver and kidney at 8 h post-injection of gadobenate dimeglumine to normal rats and diseased rats. (Kirchin, et al., 2015)
Frequently Asked Questions
- What is gadobenate dimeglumine injection used for?
Gadobenate dimeglumine injection is a magnetic resonance imaging contrast agent for the liver and central nervous system that is used to help create a clear image of the body during a scan. It enhances the detection of damage compared to unenhanced magnetic resonance images. - What are some of the factors to keep in mind when developing HPLC assays?
- Solubility studies: Determine the solubility profile and maximum absorption wavelengths.
- Chromatographic condition selection: Determine the column, mobility, and injection sample based on the results of the solubility study, retention time of the compound, and other information.
- Determination of gradient or isocratic mode
- Optimization of chromatographic conditions to improve separation: Achieve proper separation by changing mobility composition, buffer salts, pH, column, flow rate, temperature, etc.
Applications
- Gadobenate dimeglumine injection analysis plays an important role in the optimization research of its manufacturing process.
- Gadobenate dimeglumine injection analysis plays an important role in controlling its quality and ensuring the effectiveness of its application.
- Gadobenate dimeglumine injection analysis is important for cancer detection method development.
Highlights of Us
- We offer a very comprehensive analytical program for gadobenate dimeglumine injection to support our clients' research.
- All of our analytical programs for gadobenate dimeglumine injection have been validated through numerous experiments.
- We have optimized the mobile phase composition, flow rate program, flow rate, detection wavelength, and column conditions for HPLC analysis through numerous experiments.
At CD BioGlyco, our deep scientific expertise in detection method development, and validation enables us to provide our clients with high-quality pharmaceutical analytical solutions. In addition to gadobenate dimeglumine injection, we offer analytical services for Inosine and Glucose Injection, Heparin Calcium, etc. Please feel free to contact us for more information about pharmaceutical analysis.
Reference
- Kirchin, M.A.; et al. Compensatory biliary and urinary excretion of gadobenate ion after administration of gadobenate dimeglumine (MultiHance®) in cases of impaired hepatic or renal function: a mechanism that may aid in the prevention of nephrogenic systemic fibrosis? The British Journal of Radiology. 2015, 88(1048): 20140526.
