Antibodies against glycoproteins or glycopeptides generally recognize the peptide backbone as a portion of the binding epitope. Therefore, CD BioGlyco has developed a highly sensitive glycopeptide microarray platform to help our customers screen antibodies against specific glycopeptide antigens. We look forward to providing you with professional and rapid solutions in the research related to glycobiology microarray.
Abnormal post-translational variants of proteins may induce autoantibodies, and the change of O-linked glycosylation is one of the most significant cancer-related post-translational modifications. Short aberrant O-glycans on proteins may introduce new glycopeptide epitopes that can trigger autoantibodies. Therefore autoantibodies against cancer antigens are expected to serve as biomarkers for early cancer detection.
Currently, a new technology of glycopeptide microarray is being developed to screen for antibodies against different glycopeptide antigens and to detect glycopeptide-specific autoantibodies. Glycopeptide microarrays offer the advantages of parallelism, automation and rapidity. The parallel data detected has less error and higher precision. The emergence of this technology has played an important role in the advancement of many disciplines such as biology, genetics, clinical laboratory medicine and oncology.
Fig.1 Microarray platform for detection of MUC1 O-glycopeptide–specific antibodies. (Wandall, 2010)
CD BioGlyco has developed glycopeptide microarray technology to help our customers map antibody epitopes and identify key residues for glycopeptide binding. Services we provide include but are not limited to:
With a large and well-equipped platform, CD BioGlyco provides high-quality glycopeptide microarray services to clients around the world, and we have comprehensive capabilities to meet your specific needs on glycopeptide microarray analysis. If you need our services, please contact us for more details and technical support.