CD BioGlyco

Metabolic reprogramming has been a hot topic in recent years, including glycolysis and lactic acid modification in recent years. Nowadays, "mannose" has also come into everyone's sight, leading to a new research angle. On January 13, 2025, the team of Guideng Li of the Chinese Academy of Medical Sciences & Peking Union Medical College published […]

Introduction to Glycosylation Modification Glycosylation modification is a common post-translational modification process in cells, involving the covalent attachment of one or more sugar groups to proteins or other organic molecules. This modification affects protein folding, stability, activity, and intercellular signaling. There are two main types of glycosylation modification: N-glycosylation and O-glycosylation. For example, many cell […]

When the resolution is raised from 3 Å to 2.3 Å, a magical world emerges: an unprecedented 5',5'-phosphodiester bond is directly observed, weaving adjacent sugar chains into a sugar network! You don't know until you "see", the world is really amazing! However, what has been reported so far is only a superficial observation, and a […]

Corn Endosperm Filling and Storage Material Synthesis Corn is commonly used as feed, and is also an important energy and industrial raw material. The endosperm accounts for about 90% of the dry weight of corn kernels, which largely determines the kernel weight and nutritional quality of corn kernels. Therefore, studying the regulation of endosperm filling […]

In recent years, breakthroughs in nucleic acid modification and delivery vectors have brought about a wave of innovative transformational therapies. Among them, nucleic acid drugs, which are considered to be the third generation of innovative drugs after small molecule drugs and antibody drugs, have experienced explosive growth. Its advantages lie in a wide range of […]

Carbohydrates are not only important energy sources for life activities, but also store important biological information in the glycogroup (glycan structure), which participates in regulating cell fate, energy supply, and the balance between health and disease. As intracellular conditions (metabolic stress, growth factors, cytokines) are stimulated, the glycan structure will undergo aberrant glycosylation modifications due to remodeling, […]

Now that defense and immune response to pathogens have become the object of intense research, antibodies are integral to host defense mechanisms. The circulation’s most common antibody, IgG, is thought to be involved in the defense against viral and bacterial infections, and especially the Glycosylation of its fragment crystallizable (Fc) soluble part plays a major role […]

One of the hottest new cancer treatments are Antibody-Drug Conjugates (ADCs). 15 ADCs are approved so far and over 210 are in clinical trials. The ADC drug development has entered a phase of proliferation over the past couple of years on several target (HER2, EGFR, Trop2, CLDN18.2, Nectin-4), with high efficacy and safety. Drug combination therapy and […]