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Monosaccharide-based Biodegradable Material Development

Client Satisfaction Is Our Pursuit

CD BioGlyco provides a monosaccharide-based biodegradable material development service to meet specific material development and application needs. Our service is used for a wide range of biomedical, food packaging, agricultural applications, etc., and includes polymer design and synthesis, polymer processing, material preparation, analysis, and characterization. With our extensive knowledge and experience in the Development of Carbohydrate-based Biodegradable Materials, we have prepared a variety of biodegradable materials such as hydrogels. The biodegradable material development process is as follows:

Preparation of monosaccharide-based biodegradable materials

We mainly use two development strategies to prepare monosaccharide-based biodegradable materials.

Monosaccharide modification: Obtaining new monomers from chemical modification of monosaccharides to synthesize polymers, including functionalization at C-1, C-2, and C-3 positions.
Blending with other substances: Blending with other biodegradable fillers (e.g. starch, chitosan, etc.) to prepare polymers.

Our goal is to develop materials with good biocompatibility, mechanical strength, biodegradability, and non-toxic degradation products. When designing polymers, we look at the polymer chain end groups, monomers, and their respective ratios, etc., to meet the exact needs and goals of our clients.

Analysis of biodegradable materials based on monosaccharides

We analyze materials in a comprehensive and detailed manner through biodegradability testing and physical, chemical, and biological characterization.

Biodegradability determination
Physical characterization: Tensile testing, compression testing, differential scanning calorimetry (DSC) analysis, scanning electron microscope (SEM) analysis, etc.
Chemical characterization: Elemental analysis, dynamic light scattering (DLS) analysis, nuclear magnetic resonance (NMR) analysis, etc.
Biological characterization: Biocompatibility testing, antibacterial activity testing.

Fig.1 Flowchart of monosaccharide-based biodegradable material development. (CD BioGlyco)

Glucose-based Biodegradable Material Development

Glucose is widely used to prepare various biodegradable materials due to its good biocompatibility and natural bioactivity. CD BioGlyco has novel technology to enhance the properties of glucose-based biodegradable materials.

Mannose-based Biodegradable Material Development

Mannose-based polymers are good candidates for replacing plastic packaging. CD BioGlyco synthesizes polymers by modification and polymerization of mannose to prepare biodegradable materials.

Publication Data

Technology: Photopolymerisation

Journal: Materials

IF: 3.4

Published: 2022

Results: In this study, two glucose monomer derivatives 2,3,4,6 tetra-O-acetyl-1-acryloylglucopyranose (AGlc) and 2,3,4,6-tetra-O-acetyl-1 methacryloyl-glucopyranose (MGlc) were synthesized. Then homopolymers were prepared by polymerization of these two monomer derivatives by photopolymerisation. The properties of the homopolymers were examined and the results showed that the homopolymers of AGlc and MGlc had good heat resistance and transparency and were biodegradable. This study provides an effective strategy for the development of biodegradable materials based on monosaccharides.

Fig.2 Synthesis of new derivatives of glucose: AGlc and MGlc. (Gawdzik, et al., 2022)

Frequently Asked Questions

What are the factors affecting the performance of monosaccharide-based biodegradable materials?

There are many factors that affect biodegradable properties. The chemical properties of the polymers including surface morphology, molecular weight, distribution, chemical structure, crystallinity, etc., all affect the material properties. The effect of these factors on the mechanical properties, biodegradability, and biocompatibility of the material should be considered during the design and preparation process.

What factors need to be considered when developing monosaccharide-based scaffolds for tissue engineering?

The material must have a porous network that is biocompatible, biodegradable, and mechanically strong. It also needs to contain biochemical cues or surface chemistry for cell attachment, nutrient and waste movement, structural support, and promotion of cell proliferation and differentiation. In addition, the material must be non-toxic in terms of the substances produced during degradation.

Applications

Wastewater treatment: Monosaccharide-based biodegradable materials are used to sustainably remove contaminants from water, including oils and aromatic solvents.
Drug delivery: Monosaccharide-based biodegradable materials are used to present drugs to the active sites in the body required for drug release.
Antimicrobials and wound healing: Monosaccharide-based biodegradable materials are used to reduce bacterial film formation and promote wound healing.

Advantages of Us

The mechanical properties of monosaccharide-based biodegradable materials are customized.
We continue to innovate and expand our technology. Our innovative spirit has earned us the long-term trust of our clients.
Our core competencies allow us to focus on where our clients need us the most, ensuring proper staffing, and quality control of our products.

CD BioGlyco is the preferred provider of monosaccharide-based biodegradable material solutions. We support and assist our clients throughout the entire cycle from early material design and preparation to analysis. Welcome to contact us with your needs and requirements if you are interested in our monosaccharide-based biodegradable materials development services. Our research team will be the first to contact you.

References