α1-Acid glycoprotein (AGP) is a high-glycosylated, negatively charged plasma protein with anti-inflammatory and/or immunomodulatory activities. CD BioGlyco has successfully developed a highly sensitive glyco-biomarker AGP assay platform combining first-class techniques with the experienced research team to provide customers with scientific assistance in glycomics.
AGP, also known as orosomucoid, is one of the most highly glycosylated proteins in human plasma, exhibiting an abnormally high degree of glycan branching and being one of the plasma proteins with not only di- and tri- antennary, but also tetra- antennary glycans. AGP has a variety of physiological roles, including immunomodulation, binding and transporting of neutral or basic compounds including drugs, maintenance of capillary barrier function, and metabolic regulation. AGP is an acute-phase protein and the concentration of AGP in blood will increase after various states such as cancer, infection, injury and obesity.
Detection of inflammatory biomarkers, including AGP, is usually performed by ELISA or automated immunoturbidimetric methods using serum in a laboratory setting, which are complex and expensive. The development of easier and cheaper alternative quantification methods is important to provide monitoring or prognostic tools for populations at risk of nutritional deficiencies or chronic disease. In addition, an increasing number of studies are focusing on alternatives to blood sampling, containing urine and saliva, to supplement and expand our diagnostic abilities for nutritional and inflammatory biomarkers.
Fig.1 A flow immunoassay method for the quantification of AGP in human serum, urine, and saliva. (Bmga, 2019)
CD BioGlyco focuses on developing multiple reliable and detailed assays for glyco-biomarker AGP detection and analysis. The services we provide include but are not limited to:
CD BioGlyco has established highly accurate and stable AGP detection strategies to provide the most diverse portfolio of glycoprotein detection products and services. It is our mission to shorten the research time and ensure the reliability of the results. If you are interested in our services, please contact us for further information.