Josamycin Propionate Analysis Service

Josamycin Propionate Analysis Service

Trust in Our Expertise, Rely on Our Accuracy to Provide Josamycin Propionate (JP) Analysis

JP, C45H73NO16, is obtained by acylation of josamycin at position C9. It is a semi-synthetic 16-membered-ring macrolide and belongs to the macrolide class of antibiotics. CD BioGlyco provides various simple, sensitive, and selective analysis services for JP.

Fig.1 The structural formula of JP. (CD BioGlyco)Fig.1 The structural formula of JP. (CD BioGlyco)

JP Analysis Service at CD BioGlyco

  • Fundamental analysis
    • CD BioGlyco provides basic surface analyses including color, powder condition, and solubility test services. We also offer precision loss of drying measurement and incineration residues-heavy metals analysis services. Each step of the process test is strictly controlled.
  • Biophysical analysis
    • CD BioGlyco provides some professional analysis services such as ultraviolet-visible (UV) spectroscopy, infrared spectroscopy (IR), dynamic light scattering (DLS), and nuclear magnetic resonance (NMR) analysis.
    • Thin-layer chromatography (TLC) analysis
      CD BioGlyco provides a rapid test service for JP purity by TLC analysis. Our researchers provide a determination service by comparing the position and color of the main spot on a silica gel thin layer plate between the JP solution to be tested and the standard solution. We provide plate-making and deployment solvent systems according to the client's needs.
    • Chromatographic analysis
      • Related material analysis: Our researchers optimize the by-response surface method for key factors in high-performance liquid chromatography (HPLC) separation such as (strong solvent retention, mobile phase pH, column temperature, etc.) to provide high-specificity HPLC analysis service.
      • Individual ingredients analysis: We identify individual components and unknown identity impurities in Pharmaceuticals by ion trap mass spectrometer and fragmentation information analysis.
  • Microbiological verification
    • According to the parallel line principle design of quantitative reaction, we detect the inhibitory effect of antibiotics on microorganisms by cap-plate method and turbidimetry and calculate the antibiotic activity (potency).

Fig.2 Schematic diagram of JP analysis tools. (CD BioGlyco)Fig.2 Schematic diagram of JP analysis tools. (CD BioGlyco)

Publication Data

Technology: Liquid chromatography-ion trap mass spectrometry (LC-MS), X-ray crystallographic analysis, NMR,  electron ionization mass spectrometry (EI-MS), Chemical ionization mass spectrometry (CI-MS), HPLC

Journal: Journal of mass spectrometry

Published: 2004

Results: In this work, HPLC and LC-MS were used to characterize the 16-membered ring macrolide JP and to identify impurities in the complex. The advantage of this method is that no separation and purification is required. The researchers used the MS/MS and MSn collision-induced dissociation (CID) spectra of JP as a template to analyze 18 unknown compounds in combination with functional group fragmentation.

Fig.3 [M + H]+ CID spectrum of HPLC isolated JP peaks. (Govaerts, et al., 2004)Fig.3 [M + H]+ CID spectrum of HPLC isolated JP peaks. (Govaerts, et al., 2004)

Applications of JP Analysis

  • JP analysis promotes the impurity spectrum analysis and control of anti-infective drugs and is the key to the development of methodology.
  • JP analysis provides a new approach to the development of analytical methods for other macrolide antibiotics.
  • JP's in-depth analysis further identifies a variety of compounds, facilitating the discovery of more of the semi-synthetic derivative JP.

Advantages of Us

  • Our highly exclusive HPLC analysis service is very suitable for the analysis of the complex composition of macrolide antibiotics.
  • For Pharmaceutical and Biological, we provide the most efficient and reliable analytical service for our clients
  • Our staff has extensive experience in the industry and helps clients to quickly plan and analyze projects based on sample characteristics.

CD BioGlyco has a mature research team, and a strict control system to provide clients with pharmaceutical analysis services. Our serious service attitude and efficient service quality are recognized by clients around the world. Our staff always serve you with a philosophy of enthusiasm and professionalism. Please feel free to contact us.


  1. Chepkwony, H.K.; et al. Development of a liquid chromatography method for the assay and purity testing of josamycin propionate. Journal of separation science. 2003, 26(6-7): 489-495.
  2. Govaerts, C.; et al. Application of liquid chromatography-ion trap mass spectrometry to the characterization of the 16-membered ring macrolide josamycin propionate. Journal of mass spectrometry. 2004, 39(4): 437-446.
This service is for Research Use Only, not intended for any clinical use.

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CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

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