Similar in concept to the genome or proteome, glycome is a complete set of glycans and glycoconjugates generated by a cell or organism under specific conditions. Unlike amino acids in proteins or nucleotides in DNA, the monosaccharide units in glycan chains can be interconnected in many distinct ways, so there is no direct template or standard pattern for their biosynthesis. In addition, the structural diversity of oligosaccharide branches, the increased diversity of complex terminal saccharides, and various chemical modifications such as acetylation, phosphorylation, and sulfation, further increase the structural complexity of glycans. These great structural diversities enable glycans to encode a wide range of information, including cellular signaling, molecular recognition, and immune responses.
Identifying and analyzing the structure, quantity, and function of glycans is challenging. However, in recent years, this task has become easier with the advancement of science and technology and the continuous efforts of researchers. A variety of high-resolution and highly sensitive methods are now available, including mass spectrometry-based methods, high-performance liquid chromatography (HPLC), and lectin-based technologies.
Fig.1 Example of a glycomics and glycoproteomics analysis of an affinity purified serum glycoprotein. (Pauline, 2017)
CD BioGlyco owns a variety of powerful tools for high-throughput analysis of N-glycans and provides customers with a wide range of high-precision analysis services.
CD BioGlyco provides a comprehensive analysis of O-glycans using various strategies based on mass spectrometry. Our integrated service can provide customers with all-around data and detailed data analysis.
CD BioGlyco has established various methods based on mass spectrometry technology for the detection of glycans structures. Our strategies are able to accelerate clients' scientific research and reduce research costs.
CD BioGlyco has a systematic and advanced platform to provide customers with high-quality service of glycan profiling by HPLC.
CD BioGlyco is a first-class company in the field of glycobiology, and our countless successful cases have won us a lot of praise in the international arena. We hope to start the exploration of glycobiology with you. If you are interested in our services, please contact us for more detailed information.