Mitochondria are the center of cellular energy metabolism, and the tricarboxylic acid cycle that occurs in mitochondria is a common metabolic pathway in aerobic organisms. Glucose, fat, and amino acid catabolism will eventually enter the TCA cycle for oxidative energy supply. At the same time, the TCA cycle is also the hub of glucose, fat, and amino acid metabolism.
CD BioGlyco can provide a specific analysis of glucose metabolism in the whole process of the TCA cycle. Help customers understand in detail the role of the TCA cycle pathway in cancer metabolic reprogramming, analyze changes in the genome, changes in metabolites, changes in metabolic flux, and changes in protein expression and modification during metabolism, in order to find targeted TCA cycle new therapeutic strategies for the acid cycle pathway.
Fig. 1 Transporters, fuels, enzymes, and biochemical reactions driving the TCA cycle (Anderson NM, et al., 2018)
Although early studies suggested that cancer cells bypass the TCA cycle mainly through aerobic glycolysis for survival, increasing evidence suggests that cancer cells with dysregulated expression of oncogenes and tumor suppressor genes mainly rely on the TCA cycle for the maintenance of rapid proliferation of cancer cells. Therefore, studying genome-level changes in the TCA cycle can provide new insights into cancer metabolism and cancer progression.
TCA cycle metabolites are not only common intermediates in biosynthesis and energy metabolism, they may act as cytokines in cancer progression, acting as ligand activators or signaling pathway inhibitory signals to regulate the energy supply for cancer cells. We are able to provide an analysis of metabolite changes throughout the TCA process and further study the function of TCA metabolites in cancer progression based on the results obtained.
We provide metabolic flux analysis targeting the TCA pathway, analyzing rates of nutrient uptake and secretion by cancer cells, and providing direct and quantitative information on alterations in glucose metabolism in the TCA pathway.
CD BioGlyco provides multi-omics analysis for cancer cell TCA cycle, including genomics, proteomics, metabolomics, and metabolic fluxomics, to help customers gain a comprehensive understanding of cancer cell TCA cycle. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.
CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.