Glycan Structure Analysis

The elucidation of glycan structure and function will be one of the core contents of life science research in the post-genomic era. CD BioGlyco has systematic experimental system and first-class data processing platform, which can fully meet the needs of customers for glycobiology research. We have confidence to be your essential research assistant in the field of glycobiology. 

Background

Carbohydrates are often referred to as glycans and are physiologically essential. They play a key role in every biological process. The molecular structure of glycans is ever-changing. There are oligosaccharides and polysaccharides, which can be linear or branched, and their monomers can be connected in many different combinations. The huge structural diversity enables glycans to encode a wealth of information including cell signals, immune responses and molecular recognition. However, this inherent structural diversity and complex biosynthesis have brought analytical challenges to glycoscience research. Complexity in glycan structures is due to the fact that monosaccharide units can be conjugated to each other in many different ways, and their biosynthesis lacks a direct template, as opposed to amino acids in proteins or nucleotides in DNA, which are always conjugated together in a standard manner. This is also one of the main reasons why glycomics seems to be still in its infancy compared with the rapid development of genomics and proteomics. The study of glycan structure requires a combination of high-throughput technologies to reliably identify glycan structures.

A generic glycan illustrating the structural features which lead to the immense diversity in this class of biomoleculesFig 1. A generic glycan illustrating the structural features which lead to the immense diversity in this class of biomolecules (Mucha, E.; et al. 2019)

Services

At CD BioGlyco, we use the the following methods to perform glycan structure analysis.

  • Glycans are released by chemical method or enzymatic method. We provide a variety of chromatographic techniques (including HILIC, PGC, CE or anion exchange chromatography) for the analysis. This process requires the use of ultraviolet chromophores or fluorescent labels for sample derivatization. Mass spectrometry (MS) and tandem mass spectrometry (MSn) are used the most, and the combination of ion mobility and mass spectrometry (IM-MS) become a promising orthogonal tool for the analysis of biomolecules.
  • Gas-phase infrared(IR)spectroscopy is a highly sensitive method for identifying glycosides.

Applications

  • Research on the macro/micro heterogeneity of glycan
  • Research on biological function of glycan in cell signal transduction
  • Glycoprotein function research
  • Disease diagnosis and treatment research

Advantages of Us

  • Combination of multiple technology platforms
  • Technologies keep up with international development trends
  • High sensitivity, selectivity and high throughput
  • One-stop service

CD BioGlyco provides services that combine a variety of glycobiology technology platforms to obtain systematic and accurate experimental data under the operation of well-trained researchers. We use professionalism and efficiency to complete customer’s orders and save time and funds for customers.

Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.

Reference:

  1. Mucha, E.; et al. In-depth structural analysis of glycans in the gas phase. Chemical Science. 2019.
This service is for Research Use Only, not intended for any clinical use.

About Us

CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

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