Ribostamycin Sulfate Analysis Service
Unveiling the Secrets of Ribostamycin Sulfate: Reliable Analysis Services for Every Need
CD BioGlyco is a worldwide leading company in the field of glycobiology and offers many types of Pharmaceutical and Biological Analysis Services to our clients. Among them, ribostamycin sulfate, an aminoglycoside with broad-spectrum antimicrobial effects, is widely used in pharmacokinetic and nephrotoxicity research, and therefore, we provide our clients with trustworthy ribostamycin sulfate analysis services. Our analysis of ribostamycin sulfate includes but is not limited to, the following.
- Identification
Chromatography: The appropriate amount of the sample to be tested and the ribostamycin sulfate standard are taken and diluted with water respectively. Then inject it into the chromatograph for analysis. Finally, we compare the peak position and time of the two solutions, if the position and time are the same, it means that the sample to be tested is ribostamycin sulfate. - Acid-base
The appropriate amount of sample to be tested is weighed, dissolved, and diluted with water, and the pH meter is used to test the pH. - Structure and molecular weight
Taking a small amount of the sample to be tested, we provide multi-dimensional nuclear magnetic resonance (NMR), and infrared spectroscopy (IR) to test its structure. We provide gel permeation chromatography (GPC) and mass spectrometry (MS) to test the molecular weight. - Content and related substances
Under selected chromatographic conditions, we offer a high-performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) method for the determination of ribostamycin sulfate content and related substances. The method has the advantages of stability, simple operation, and accurate structure. - Loss on drying
The product is taken and dried under reduced pressure with phosphorus pentoxide as a drying agent at a special temperature to constant weight and the weight loss is calculated. - Bioactivity
We offer in vitro assays to test the activity of ribostamycin sulfate. For example, we co-culture strains of bacteria with ribostamycin sulfate to test their antimicrobial properties.
Fig.1 Ribostamycin sulfate analysis services. (CD BioGlyco)
Publication Data
Technology: In vitro experiment
Journal: Frontiers in Microbiology
IF: 5.2
Published: 2020
Results: In this article, the authors tested five aminoglycosides for antimicrobial activity using in vitro experiments. Of these, eight of the bacterial strains tested were associated with gastrointestinal infections. The results showed that the minimum inhibitory concentration strains of riboflavin ranged from 0.9-7.2 μM against Escherichia coli and 0.5 μM against Haemophilus influenza. The authors also found that the minimum inhibitory concentration of riboflavin was greatly increased from 57.2 to 7.2 μM-fold when the bacteria were treated with a combination of riboflavin sulfate and ethylenediaminetetraacetic acid. Such findings demonstrate promising ways to increase the clinical potential of ribostamycin.
Advantages
- We have a professional Pharmaceutical Analysis Service team and first-class analysis technology to provide custom analysis solutions for our clients.
- The analysis solutions we provide undergo strict quality testing to ensure reliability.
- We provide our clients with professional analysis reports and detailed data analysis.
CD BioGlyco has extensive experience in the analysis of pharmaceuticals and biologicals, providing custom analysis solutions to clients around the world. With world-leading technology in pharmaceutical analysis, our services are characterized by high quality and reliability. If you would like information on pharmaceutical analysis, please feel free to contact us.
Reference
- Kong, J. et al. Exploration of antibiotic activity of aminoglycosides, in particular, ribostamycin alone and combination with ethylenediaminetetraacetic acid against pathogenic bacteria. Frontiers in Microbiology. 2020, 11: 1718.
