Carbohydrates are present in almost all living organisms and are involved in energy storage, molecular transport, protein folding, biological recognition, and signal transduction. CD BioGlyco provides a wide range of carbohydrate products for the life sciences and chemical research fields, such as cyclodextrins, N-glycan, O-glycan, and cellulose.
The sugar metabolic labeling is to transfer non-natural sugar molecules with specific groups into the cell for glycosylation and the transferred oligosaccharides will carry specific groups. These oligosaccharides carrying specific groups react with fluorescent label molecules. CD BioGlyco provides researchers with sugar-alkyne products and sugar-azide products that can be used in labeling reactions, such as 6-azido-6-deoxy-D-galactose.
Fluorine-modified sugar products are typically produced by introducing one (or more) fluorine atoms into the carbohydrate structure through deoxyfluorination chemistry. These products have a wide range of applications in glycoscience, such as donor or acceptor substrates in glycosylation reactions. CD BioGlyco provides various high-quality fluorinated derivatives, such as 6-fluoro-N-acetylgalactosamine, 2-deoxy-2-fluoro-L-fucose. Please find more information about our fluorine-modified sugar products at CD BioGlyco.
Sugar-PEG products are a class of PEG linkers that contain a sugar structure on one side and a reactive chemical group on the other. CD BioGlyco has developed various sugar-PEG products with reactive chemical groups such as allyl, amine, thiol, azide, alkyne, and carboxyl. These products can be used for bioassays and bioconjugations.
We offer many simple monosaccharide products (e.g. allose, glucose, fructose, xylose, mannitol, arabinose), glycosides (e.g. mannopyranoside, glucopyranoside, galactopyranoside, arabinopyranoside), and monosaccharide derivatives (e.g. β-L-fucopyranosyl phosphate, 3-deoxyribose) in milligram to kilogram quantities. These products are strictly quality-controlled to ensure purity and structure.
Disaccharides are carbohydrates formed by two monosaccharide units linked together by α or β glycosidic bonds and play an important role in food, medicine, and biotechnology. CD BioGlyco is a professional glycobiology company dedicated to helping global companies, universities, and research institutions solve their difficulties and problems in the field of glycobiology. We provide clients with high-quality and worry-free disaccharide products, which are measured by mass spectrometry, high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), and other technologies to ensure product quality. If you are interested in higher purity products, please feel free to contact us and our scientists will provide you with customized solutions.
We provide clients with the following disaccharides and their derivatives:
CD BioGlyco provides a variety of high-quality blood group products, such as Lewis A trisaccharides, Lewis A tetrasaccharides, Lewis A pentasaccharides, and blood group A trisaccharides. We also have many blood groups and Lewis antigen derivatives for you to choose from, such as amine derivatives, and ester derivatives. We couple blood group and Lewis antigens with a variety of molecules to obtain high-quality conjugates, such as sepharose FF, sepharose 4B, biotin, bovine serum albumin (BSA), human serum albumin (HSA), keyhole limpet hemocyanin (KLH).
HMOs are the third-largest solid component in breast milk after fat and lactose. They are composed of D-glucose, D-galactose, N-acetylglucosamine, L-fucose, and N-acetylneuraminic acid. The physiological functions include regulating the intestinal flora, defending against infections of the respiratory system and urinary system, improving the body's immunity, and promoting infant brain development. CD BioGlyco provides many types of HMOs for clients, such as 2'-fucosyllactose, lactodifucotetraose, lacto-N-triose I, 3'-sialyllactose, lacto-N-fucopentaose I, sialyllacto-N-tetraose a.
Glycoconjugates, carbohydrates covalently linked to other biomolecules, have proven to be invaluable tools. We couple various oligosaccharides with polyacrylamide (PAA), biotin, PAA-biotin, and PAA-fluorescein (FITC) to obtain a wide range of glycoconjugate products, such as GlcNAcβ(1-2)Galβ(1-3)GalNAcα-Sp3-PAA, GlcNAcβ(1-2)Galβ(1-3)GalNAcα-Sp3-Biotin, GlcNAcβ(1-2)Galβ(1-3)GalNAcα-Sp3-PAA-Biotin, and GlcNAcβ(1-2)Galβ(1-3)GalNAcα-Sp3-PAA-FITC. These products are used in the research of vaccines, adjuvants, and many other applications. In addition, we are always ready to help our clients design and produce new glycoconjugates, constantly expanding our glycoconjugate library.
Cyclodextrin is a class of cyclic oligosaccharides composed of glucose subunits connected by α-1,4-glycosidic bonds. The unique ring structure of cyclodextrin forms a hydrophobic central cavity and a hydrophilic outer surface, which forms inclusion complexes with various guest molecules. CD BioGlyco provides clients with α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin products from milligram to kilogram scale for drug delivery, cosmetic formulations, environmental applications, etc. In addition, we also have many high-quality cyclodextrin-derivatives products, such as fluorescently labeled cyclodextrin, cyclodextrin polymers, carboxymethylated cyclodextrin, succinylated cyclodextrin, and sulfobutylated cyclodextrin.
N-linked glycans are sugar chains linked to the amide nitrogen of asparagine residues in protein molecules. The most common O-linked glycans are mucin-type glycans, which contain an initial GalNAc residue and have eight mucin-type core structures. CD BioGlyco is the world's leading glycan supplier, providing the world's most comprehensive list of N- and O-glycan products. Our products range from simple mannose compounds, core 1 O-glycan to complex N-glycans, and complex sulfated mucin-type glycans. Meanwhile, we will continue to expand the available N- and O-glycan products to meet customers' needs.
In addition, we have many other types of oligosaccharide products for you to choose from, such as maltotetradecaose, ulvan oligosaccharides, and guluronate oligosaccharides. If you have special product requirements, we also provide Customized Oligosaccharide Synthesis Services.
GAGs are a class of highly sulfated, complex, polydisperse linear polysaccharides. GAGs are involved in a variety of protein interactions in physiological and pathological processes and also contribute to the structural integrity of the extracellular matrix and connective tissue. At CD BioGlyco, we provide our clients with high-quality GAG and its derivative products such as heparin, heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS) and hyaluronic acid (HA) for glycobiology research.
We provide starch products extracted from potato, corn, rice, wheat, etc., and derivatize them to obtain modified starch, carboxymethyl starch, hydroxyethyl starch, etc.
We have chitosan products with different molecular weights, such as low molecular weight, medium molecular weight, and high molecular weight. These chitosans are also coupled with rhodamine, Maleimide, biotin, FITC, thiol, etc. to obtain chitosan conjugates with different molecular weights. We also have many derivatized chitosan products, such as trimethyl chitosan, glycol chitosan methacrylate, PEGylated chitosan, and methylglycol chitosan.
We have ethyl cellulose, hydroxyethyl cellulose, methylcellulose, and carboxymethyl cellulose products with different viscosities for clients to choose from. We also have conjugate products of cellulose coupled with rhodamine, biotin, FITC, etc.
We also have a wide range of other polysaccharides such as dextran, peptidoglycan, levan, laminarin, glycogen, chitin, carrageenan, cellopentaose, and fucoidan.
Technology: GAG-based nanoparticles
Journal: Biomolecules
Published: 2021
IF: 4.8
Results: Studies have found that the molecular weight, distribution, composition and fine modification of GAG are closely related to the development of cancer, and GAG-based drugs have always been the focus of scientists. Here, the author introduces the role of GAG (heparin and heparan sulfate, chondroitin sulfate/dermatan sulfate, keratan sulfate, hyaluronan) in cancer changes, GAG-based nanoparticles for targeted drug delivery, the application prospects of GAG in targeted cancer, GAG in immunology, and GAG as a potential biomarker for cancer treatment response.
Fig.1 Mechanism of action of HA-based nanoparticles. (Berdiaki, et al., 2021)
CD BioGlyco aims to provide clients with high-quality carbohydrate products that drive innovation and excellence, supporting the continuous advancement of the glycobiology industry. If you are interested in our products, please feel free to contact us for a quote and more information.
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