High-Throughput Screening for Human Galactokinase Inhibitors

High-Throughput Screening for Human Galactokinase Inhibitors

The Significance of Developing Human Galactokinase Inhibitors

Human galactokinase is an important regulatory enzyme, also known as "LCT" or "lactase", that catalyzes the metabolism of galactose in the metabolic pathway and is of great importance for glucose metabolism. It is mainly found in the human digestive system, especially on the surface of the small intestinal villi. The deficiency of human galactokinase is one of the main causes of the body's inability to break down and absorb lactose, thus causing symptoms of lactose intolerance. Many studies have shown that excessive activation of human galactokinase is associated with the development of several diseases, such as diabetes, obesity, and other metabolic disorders. Therefore, the development of galactokinase inhibitors is a promising therapeutic approach. The key to achieving the high-throughput screening (HTS) of galactokinase inhibitors is to establish an effective screening system. Consequently, efficient assays for galactokinase activity are needed to assess the inhibitory effects of candidate compounds.

The human galactose metabolic pathway.Fig.1 The human galactose metabolic pathway. (Wierenga, et al., 2008)

HTS of Human Galactokinase Inhibitors at CD BioGlyco

CD BioGlyco has the latest technology and equipment to screen large numbers of samples quickly and accurately. Our company provides comprehensive high-throughput human galactokinase inhibitors screening services, with specific services including:

  • HTS for human galactokinase inhibitors using 19F-Labeled Probes
    The 19F-labeled probes enable efficient selection against target compounds, allowing rapid identification of inhibitors from complex mixtures of compounds.
  • HTS for human galactokinase inhibitors using Hydrophilic Interaction Chromatography (HILIC)
    This technology is effective for the separation of polar compounds, allowing the separation of different compounds and their quantitative analysis. It can avoid the effect of some interferents on the detection of human galactokinase inhibitors.
  • HTS for human galactokinase inhibitors using the Microchip-Based Assay
    The microchip-based assay service is used to process and assay samples, allowing hundreds of samples to be analyzed at the same time, enabling large-scale analysis to be completed in a relatively short period.

The HTS process for human galactokinase inhibitors.Fig.2 The HTS process for human galactokinase inhibitors. (CD BioGlyco)


  • Finding new drug candidates
  • Helping to reveal the mechanism of action of human galactokinase inhibitors
  • Improving the efficiency of drug discovery and optimizing drug properties

Advantages of Us

  • Separation of strongly polar compounds
  • Suitable for highly hydrophilic compounds
  • High chemical stability

The HTS service at CD BioGlyco helps you find candidate compounds as human galactokinase inhibitors. We provide you with a one-stop service that includes support for experimental design, compound screening, data analysis, and conclusion generation. Our goal is to help you find the most suitable compounds to further advance research in the field of glycobiology. If you have any interest in our services, please don't hesitate to contact us for further information.


  1. Wierenga, K.J.; et al. High-throughput screening for human galactokinase inhibitors. SLAS Discovery. 2008, 13(5): 415-423.
This service is for Research Use Only, not intended for any clinical use.

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