Most biotherapeutic products are glycoproteins, including glycosyltransferases, glycosidases, erythropoietin, and cytokines. The drugs themselves are complex, but to better assess their effects, there is an urgent need to develop methods to characterize glycosylation. CD BioGlyco is a leader in glycosylation characterization. We have developed a comprehensive Glycoproteomics Platform to provide customers with the characterization of glycosylation in protein drugs. Welcome customers from all over the world to cooperate with us!
Approved therapeutic protein drugs have grown exponentially over the past few decades. These drugs are used in cancer, diabetes, neutropenia, rheumatoid arthritis, et al. This solidified the position of biologics in the drug market. Glycosylation is one of the most important post-translational modifications during protein characterization. As a key quality attribute of therapeutic protein drugs, it affects the biological activity, serum half-life, stability, and immunogenicity of the drug, changing the way the drug interacts with the patient's cells. Therefore, quantitative analytical methods are needed to accurately characterize glycosylation in biopharmaceutical processes.
The glycan portion of therapeutic proteins has been reported to significantly affect their pharmacodynamics and pharmacokinetics, as well as effects on protein folding, targeting, transport, ligand binding, and more. Therefore, scientists usually characterize glycans by high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), liquid chromatography-MS (LC-MS), capillary electrophoresis (CE), matrix-assisted laser desorption/ionization-MS (MALDI/TOF-MS), etc. For example, fluorescent LC labeled with 1,2-diamino-4,5-methylenedioxybenzene (DMB) is used for the quantification and analysis of sialic acid.
Based on the importance of glycosylation in protein drugs, CD BioGlyco provides customers with comprehensive characterization services of glycosylation in protein drugs. Our services include but are not limited to:
CD BioGlyco is committed to research in the field of glycosylation for many years, providing our customers with high-quality, cost-effective, and hassle-free glycosylation characterization services. If you are interested in our services, please feel free to contact us, we are looking forward to being your indispensable assistant in glycosylation characterization.