Glycan-binding proteins are proteins that specifically recognize and bind to carbohydrates on the surface of cells, tissues, or molecules, and some of them also function as lectins. They are involved in a wide range of biological processes. Different types of these proteins have different carbohydrate-binding domains (CBDs) that bind specific types of glycosylated substances. Some examples of glycan-binding proteins include galectins, selectins, and C-type lectins. In conclusion, glycan-binding proteins are of great importance in multiple aspects of cellular, molecular, and physiological processes. The study of their functions and regulatory mechanisms is important for a deeper understanding of fundamental questions in glycobiology and for developing disease-related research. High-throughput screening (HTS) can be used to predict small molecule compounds with binding sites and binding affinities to glycan-binding proteins. This helps researchers understand the molecular mechanisms of interactions with glycan-binding proteins and provides clues for designing new drugs or therapeutic strategies.
Fig.1 Procedure for the screening of glycan-binding proteins by miniature pig kidney N-glycan-immobilized beads and mass spectrometry. (Kim, et al., 2008)
CD BioGlyco is focused on the research of high-quality glycan-binding proteins for drug development. We are committed to combining its proprietary technology with innovative science to provide our clients with high-quality glycan-binding proteins HTS services. Our services encompass a wide range of offerings, including but not restricted to:
Fig 2. HTS technologies applied to glycan-binding proteins. (CD BioGlyco, 2023)
CD BioGlyco is committed to providing clients with the complete solution for glycosylated protein analysis, including HTS services of glycan-binding proteins, to help clients achieve optimal research results and commercial benefits. If you are interested in our services, please feel free to contact us for more details.