Fucosyltransferases are a class of enzymes that catalyze the transfer reaction between algal sugar molecules. They transfer algal glycosyl groups to substrate molecules in the glycosyl assimilation pathway, provide a spatial molecular vacancy for polysaccharide synthesis, and thus promote the synthesis of polysaccharides. It is involved in many biological activities, such as the modification of cell surface component molecules, involvement in signaling processes, and interactions between pathogens and host cells. Sialyltransferase is an important enzyme involved in the synthesis and regulation of the endogenous plant hormone salicylic acid (SA), and also in the transfer reaction of salicylic acid with coenzyme A to produce acetylsalicylic acid, which is a commonly used analgesic and antipyretic. Therefore, by studying their inhibitors, it is possible to investigate their role in the development and progression of related diseases, which has important biological implications for drug development.
Fig.1 Fluorescence-polarization-based assays for sialyl- and fucosyltransferases. (Rillahan, et al., 2011)
CD BioGlyco utilizes the expertise and advanced equipment to efficiently evaluate compounds to determine the potential for application in areas such as drug discovery and development. We are committed to providing the most accurate, reliable, and rapid HTS services for Inhibitors of sialyl- and fucosyltransferases. Our HTS services handle large volumes of data and utilize state-of-the-art technologies and algorithms to efficiently filter and classify experimental data. The HTS services we offer are diverse and not limited to the following.:
Fig.2 Process of SPR-based HTS service. (CD BioGlyco, 2023)
CD BioGlyco provides a complete HTS service for inhibitors of sialyl- and fucosyltransferases to help clients save their time and cost. Regarding after-sales service, we will help our clients find the most suitable solution as soon as possible to ensure they get the best service. If you are interested in our services, please contact us for more details.