Mannose-based Biodegradable Material Development

Mannose-based Biodegradable Material Development

CD BioGlyco uses a variety of carbohydrates to prepare Biodegradable Materials. Polymers based on Monosaccharides such as mannose are candidates for biodegradable and well-biocompatible materials for common synthetic plastic materials. We provide a one-stop service for the development of mannose-based biodegradable materials from design, and preparation to analysis. Our development process is as follows:

  • Preparation of mannose-based biodegradable materials

Carbohydrate-based plastic materials are less threatening to the environment as compared to plastic materials from non-renewable petroleum resources. This is stimulating the growing demand for their applications in packaging and pharmaceuticals. We develop mannose-based nanomaterials, and hydrogels for drug delivery, tissue replacement, food packaging, and agriculture.

The poor specificity, antimicrobial, and other properties of mono-mannose-based biodegradable materials limit their applications. We first synthesize mannose polymer by modification and polymerization of mannose using various chemical methods. Afterward, biodegradable materials are prepared based on this polymer by solution casting, direct mixing, and foaming.

  • Analysis of mannose-based biodegradable materials

We have a very comprehensive material analysis process including thermogravimetric analysis (thermal stability), Fourier-transform infrared spectroscopy (FTIR) analysis, scanning electron microscopy (SEM), biodegradability testing, etc. Our goal is to develop biodegradable materials with special physical and chemical properties while ensuring good biodegradability and biocompatibility.

Flowchart of mannose-based biodegradable materialsFig.1 Flowchart of mannose-based biodegradable materials. (CD BioGlyco)

Publication Data

Technology: Free radical bulk polymerization

Journal: Polymer Degradation and Stability

IF: 4.032

Published: 2019

Results: In this study, a glycopolymer was obtained from a novel D-mannose oligomer by blending it with 2-hydroxypropyl acrylate (HPA). This glycopolymer was analyzed by thermogravimetric, FTIR, and biodegradability tests. The results showed that the polymer exhibited good heat-treatable elasticity and biodegradation sensitivity. The mannose backbones were first recognized and consumed by bacteria as a carbon nutrient source. This study provides an effective strategy for the development of mannose-based biodegradable materials.

The copolymerization reaction scheme between the D-mannose oligomer (M) and HPA.Fig.2 The copolymerization reaction scheme between the D-mannose oligomer (M) and HPA. (Pană, et al., 2019)

Frequently Asked Questions

  • What are the factors affecting biodegradation of mannose-based materials?

Biodegradation is the process of changing the structure of an organic material under microbial attack. The functional groups of the mannose-based polymers, the percentage of mannose, the structure, etc., all affect the degradation of the material. Other abiotic factors such as moisture, light, wind, etc., also affect the biodegradation properties of the material.

  • Why are mannose-based biodegradable materials used in cancer research?

Lectins with mannose-binding capacity are mainly expressed on various tumor cells, macrophages, dendritic cells, etc. They are attractive entry points for tumor therapy and immunomodulation studies. Mannose-based nanomaterials target drug delivery based on their receptor-binding ability, which ultimately reduces adverse effects and enhances therapeutic efficacy.


  • Mannose-based biodegradable materials replace petroleum-based plastics for food packaging.
  • Mannose-based biodegradable materials are used as substrates for encapsulation, stabilization, and release of active ingredients in drug delivery systems.
  • Mannose-based biodegradable materials are used for separation purposes (reverse osmosis membranes), and cell culture (mannose-based cell culture substrates).

Highlights of Us

  • We develop mannose-based biodegradable materials for a variety of applications, including compound separation, macromolecular drug delivery, and tissue engineering.
  • We modify or polymerize mannose with other compounds to obtain competitive polymeric materials with biodegradable properties.
  • We have a very comprehensive analytical program for mannose-based biodegradable materials, which analyzes the chemical, physical, and biological properties of the materials.

CD BioGlyco contributes to environmental protection through the development of new competitive materials based on renewable raw materials. With extensive experience in the development of biodegradable materials, we excel in the development of various materials. In addition to mannose, we also provide a Glucose-based Biodegradable Material Development service. Please feel free to contact us for more information on material development and analysis.


  1. Pană, A.M.; et al. Biodegradation studies on new glycopolymers derived from oligomeric D-mannose itaconates and 2-hydroxypropyl acrylate. Polymer Degradation and Stability. 2019, 167: 210-216.
  2. From Wikipedia:
This service is for Research Use Only, not intended for any clinical use.

About Us

CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

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